2013 Fiscal Year Final Research Report
The exogenous sterol uptake in pathogenic fungus, Candida glabrata
| Project/Area Number |
24790428
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
TANABE Koichi 国立感染症研究所, 国立感染症研究所 真菌部, 主任研究官 (80370964)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 病原真菌 / ステロール / ABCタンパク質 |
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| Research Abstract |
The pathogenic fungus, Candida glabrata is thought to take up exogenous cholesterol inside host body. Exogenous sterol uptake in C. glabrata was activated under iron-depleted conditions. Both ABC protein, AUS1 and mannoprotein, TIR3 was required for sterol uptake. Mouse infection model with AUS1-knockout mutant revealed that sterol uptake was thought to promote the C. glabrata survival inside host tissue.
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[Journal Article] The Candida glabrata sterol scavenging mechanism, mediated by the ATP-binding cassette transporter Aus1p, is regulated by iron limitation2013
Author(s)
Nagi M, Tanabe K, Ueno K, Nakayama H, Aoyama T, Chibana H, Yamagoe S, Umeyama T, Oura T, Ohno H, Kajiwara S, Miyazaki Y
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Journal Title
Mol Microbiol
Volume: 88(2)(*Corresponding author)
Pages: 371-81
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