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2013 Fiscal Year Final Research Report

The exogenous sterol uptake in pathogenic fungus, Candida glabrata

Research Project

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Project/Area Number 24790428
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bacteriology (including Mycology)
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

TANABE Koichi  国立感染症研究所, 国立感染症研究所 真菌部, 主任研究官 (80370964)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords病原真菌 / ステロール / ABCタンパク質
Research Abstract

The pathogenic fungus, Candida glabrata is thought to take up exogenous cholesterol inside host body. Exogenous sterol uptake in C. glabrata was activated under iron-depleted conditions. Both ABC protein, AUS1 and mannoprotein, TIR3 was required for sterol uptake. Mouse infection model with AUS1-knockout mutant revealed that sterol uptake was thought to promote the C. glabrata survival inside host tissue.

  • Research Products

    (7 results)

All 2013 2012

All Journal Article (2 results) Presentation (5 results)

  • [Journal Article] The Candida glabrata sterol scavenging mechanism, mediated by the ATP-binding cassette transporter Aus1p, is regulated by iron limitation2013

    • Author(s)
      Nagi M, Tanabe K, Ueno K, Nakayama H, Aoyama T, Chibana H, Yamagoe S, Umeyama T, Oura T, Ohno H, Kajiwara S, Miyazaki Y
    • Journal Title

      Mol Microbiol

      Volume: 88(2)(*Corresponding author) Pages: 371-81

  • [Journal Article] Serum cholesterol promotes the growth of Candida glabrata in the presence of fluconazole2013

    • Author(s)
      Nagi M, Tanabe K, Nakayama H, Yamagoe S, Umeyama T, Oura T, Ohno H, Kajiwara S, Miyazaki Y
    • Journal Title

      J Infect Chemother

      Volume: 19(1) Pages: 138-43

  • [Presentation] 病原真菌Candida glabrataにおける細胞外ステロール取り込み2012

    • Author(s)
      田辺公一、名木稔、中山浩伸、梅山隆、山越智、大野秀明、宮崎義継
    • Organizer
      第35回日本分子生物学会年会
    • Year and Date
      20121200
  • [Presentation] Candida glabrataの生体内における病原因子;鉄欠乏における遺伝子発現調節2012

    • Author(s)
      田辺公一、梅山隆、金子幸弘、山越智、大野秀明、宮崎義継
    • Organizer
      第56回日本医真菌学会総会・学術集会
    • Year and Date
      20121100
  • [Presentation] 病原真菌Candida glabrataの細胞外ステロール取り込み活性化機構2012

    • Author(s)
      田辺公一、名木稔、山越智、梅山隆、大野秀明、宮崎義継
    • Organizer
      第41回薬剤耐性菌研究会
    • Year and Date
      20121000
  • [Presentation] Candida glabrataの鉄欠乏における遺伝子発現調2012

    • Author(s)
      田辺公一、名木稔、梅山隆、金子幸弘、山越智、大野秀明、宮﨑義継
    • Organizer
      第95回日本細菌学会関東支部総会
    • Year and Date
      20121000
  • [Presentation] 病原真菌Candida glabrataはユニークなステロールトランスポーターによりアゾール耐性となりうる2012

    • Author(s)
      名木稔,田辺公一,山越智,梅山隆,大野秀明,宮﨑義継
    • Organizer
      第86回日本感染症学会総会・学術講演会
    • Year and Date
      20120400

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Published: 2015-06-25  

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