2013 Fiscal Year Final Research Report
Autoantibody production during gamma-herpesvirus infection
| Project/Area Number |
24790440
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
|
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 自己反応性免疫応答 |
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| Research Abstract |
The purpose of this study is to unveil the underlying mechanisms how autoreactive B cells emerge during viral infection. Murine gamma-herpesvirus 68 (MHV68) reportedly induced serum IgG autoantibody. Employing this model, we analyzed the reactivities of the germinal center B cells by singlecell based clonining method. It was revealed that the splenic IgG-positive germinal center B cells from MHV68-infected mice exhibited auto- and polyreactivity, which is defined as an ability to recognize multiple antigens.
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