2013 Fiscal Year Final Research Report
The regulatory mechanism for interleukin-4 induction in murine basophils
| Project/Area Number |
24790467
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Tokyo University of Science (2013)
Shinshu University (2012) |
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Principal Investigator |
ODA Akihisa 東京理科大学, 生命医科学研究所, 助教 (80547703)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | IL-4 / 好塩基球 / PIR-B |
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| Research Abstract |
Although basophils produce IL-4 in response to IL-3, we discovered that basophils lost IL-3 responsiveness upon activation. PIR-B, the negative regulatory cell curface molecule is involved in the loss of IL-3 responses in activated basophils. In addition, PIR-B also negatively regulates IgG-induced IL-4 production in activated basophils. The inhibitory mechanisms by PIR-B is mediated by ITIM independent manner.
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