2013 Fiscal Year Final Research Report
The role of PI3K-Akt-mTORC1 signaling pathway on Th17 differentiation
| Project/Area Number |
24790479
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Tokyo Medical and Dental University (2013)
Keio University (2012) |
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Principal Investigator |
NAGAI Shigenori 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (50348801)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | Th17 / PI3K / mTORC1 |
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| Research Abstract |
Th17 cell is a kind of helper T (Th) cells which causes autoimmune diseases such as rheumatoid arthritis or inflammatory bowel disease. Therefore, to clarify the molecular mechanisms of Th17 differentiation is thought to lead the effective prevention or the development of the effective therapy. In this research, we demonstrated that phosphoinositide 3-kinase (PI3K)-Akt-mTORC1 signaling pathway positively regulates Th17 differentiation.
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[Journal Article] TIM-4 glycoprotein - mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance2013
Author(s)
Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, Akiba H, Foretz M, Yoshiyama H, Kinoshita I, Dosaka,. Akita H, Takeya M, Viollet B, Yagita H, Jinushi M
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Journal Title
Immunity
Volume: 39(6)
Pages: 1070-81
DOI
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[Journal Article] CDK inhibitors suppress Th17 and promote iTreg differentiation, and ameliorate experimental autoimmune encephalomyelitis in mice2013
Author(s)
Yoshida H, Kotani H, Kondo T, Tani I, Wei X, Tsuruta S, Kimura A, Asakawa M, Ito M, Nagai S, Yoshimura A
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Journal Title
Biochem Biophys Res Commun
Volume: 435(3)
Pages: 378-84
DOI
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[Journal Article] PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ2012
Author(s)
Kurebayashi Y, Nagai S, Ikejiri A, Ohtani M, Ichiyama K, Baba Y, Yamada T, Egami S, Hoshii T, Hirao A, Matsuda S, Koyasu S
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Journal Title
Cell Rep
Volume: 1(4)
Pages: 360-73
DOI
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[Journal Article] Autoimmunity against M₂muscarinic acetylcholine receptor induces myocarditis and leads to a dilated cardiomyopathy - like phenotype2012
Author(s)
Yoshizawa A, Nagai S, Baba Y, Yamada T, Matsui M, Tanaka H, Miyoshi S, Amagai M, Yoshikawa T, Fukuda K, Ogawa S, Koyasu S
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Journal Title
Eur J Immunol
Volume: 42(5)
Pages: 1152-63
DOI
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[Presentation] Development of pulmonary alveolar proteinosis in PI3K deficient mice2013
Author(s)
Akihiro Yoshizawa, Shigenori Nagai, Yukiko Baba, Tomoyasu Nishimura, Taketo Yamada, Shigeo Koyasu
Organizer
The Joint International Meeting of The 78^<th> Meeting of the Japanese Society of Interferon and Cytokine Research and The 21^<st> International Symposium on Molecular Cell Biology of Macrophages 2013
Place of Presentation
Tokyo
Year and Date
20130520-21
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[Presentation] Development of a novel antimicrobial - coated biomedical polymer2013
Author(s)
Ishihama H, Ishii K, Nagai S, Kakinuma H, Sasaki A, Yoshioka K, Kuramoto T, Shiono Y, Aizawa M, Okada Y, Koyasu S, Toyama Y, Matsumoto M
Organizer
The International Society for the Study of Lumbar Spine (ISSLS)
Place of Presentation
Scottsdale, Arizona, USA
Year and Date
20130513-17
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[Presentation] A comparison of biofilm formation in various metal materials2013
Author(s)
Yosihoka K, Ishii K, Nagai S, Kakinuma H, Kuramoto T, Sasaki A, Aizawa M, Okada Y, Koyasu S, Toyama Y, Matsumoto M
Organizer
The International Society for the Study of Lumbar Spine (ISSLS) 2013
Place of Presentation
Scottsdale, Arizona, USA
Year and Date
20130513-17
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[Presentation] Propionibacterium acnes causes delayed surgical site infection only in the presence of implant2013
Author(s)
Shiono Y, Ishii K, Nagai S, Kuramoto T, Yoshioka K, Ishihama H, Funao H, Kakinuma H, Sasaki A, Aizawa M, Okada Y, Koyasu S, Toyama Y, Matsumoto M
Organizer
The International Society for the Study of Lumbar Spine (ISSLS) 2013
Place of Presentation
Scottsdale, Arizona, USA
Year and Date
20130513-17
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[Presentation] PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation2012
Author(s)
Shigenori Nagai, Yutaka Kurebayashi, Ai Ikejiri, Masashi Ohtani, Kenji Ichiyama, Yukiko Baba, Taketo Yamada, Shohei Egami, Takayuki Hoshii, Atsushi Hirao, Satoshi Matsuda, Shigeo Koyasu
Organizer
Inositol Phospholipid Signaling in Physiology and Disease, New York Academy of Sciences
Place of Presentation
NY,USA
Year and Date
20120000
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