2013 Fiscal Year Final Research Report
Molecular mechanism of astrocyte-related cachexia and pain due to neural invasion of pancreatic cancer
| Project/Area Number |
24790669
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
MITSUNAGA Shuichi 独立行政法人国立がん研究センター, その他部局等, 研究員 (20466197)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 緩和医療 |
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| Research Abstract |
The reaction of the nervous system to neural invasion (N-inv) may lead to cachexia and pain in pancreatic cancer (PCa). The N-inv model was created by injecting Capan-1 cells into the left sciatic nerve of severe combined immunodeficiency mice. The N-inv model was compared to a sham operation group. Propentofylline (PPF), an inhibitor of astrocytic activation, was administered daily into the abdominal cavity. Pain and body weight (BW) were measured weekly. Mice were euthanized 6 weeks after surgery.
Pain and astrocytic activation were observed 2 weeks after the start of N-inv and maintained throughout the experiment. Loss of BW began at 4 weeks and was worse at 6 weeks. PPF treatment inhibited pain, astrocytic activation, and BW loss in the N-inv model. The reaction of the nervous system to N-inv leads to cachexia in PCa. The reaction of the nervous system to N-inv leads to cachexia in PCa.
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Research Products
(15 results)
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[Journal Article] Prognostic impact of M2 macrophages at neural invasion in patients with invasive ductal carcinoma of the pancreas2014
Author(s)
Sugimoto M, Mitsunaga S, Yoshikawa K, Kato Y, Gotohda N, Takahashi S, Konishi M, Ikeda M, Kojima M, Ochiai A, Kaneko H
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Journal Title
Eur J Cancer
Volume: 50(11)
Pages: 1900-8
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[Presentation] Phase I/II study of lenvatinib (E7080), a multitargeted tyrosine kinase inhibitor, in patients (pts) with advanced hepatocellular carcinoma (HCC) : Phase I results2013
Author(s)
Shuichi Mitsunaga, Masafumi Ikeda, Hideki Ueno, Kohei Nakachi, Chigusa Morizane, Shunsuke Kondo, Satoshi Shimizu, Yasushi Kojima, Takuya Suzuki, Toshiyuki Tamai, James P. O'Brien, Takuji Okusaka
Organizer
ASCO-GI2013 Gastrointestinal Cancers Symposium
Place of Presentation
San Francisco
Year and Date
20130124-26
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[Presentation] Phase I study of safety, pharmacokinetics, and efficacy of TSU-68 plus S-1 combination in patients with advanced hepatocellular carcinoma2013
Author(s)
Masafumi Ikeda, Shuichiro Shiina, Kohei Nakachi, Shuichi Mitsunaga, Satoshi Shimizu, Yasushi Kojima, Hideki Ueno, Chigusa Morizane, Shunsuke Kondo, Yasunari Sakamoto, Ryosuke Tateishi, Yoshinari Asaoka, Kazuhiko Koike, Hitoshi Arioka, Takuji Okusaka
Organizer
ASCO-GI2013 Gastrointestinal Cancers Symposium
Place of Presentation
San Francisco
Year and Date
20130124-26
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