2013 Fiscal Year Final Research Report

Micro RNA expressions of chronic hepatitis related hepatocellular carcinoma

Research Project

Project/Area Number	24790686
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Gastroenterology
Research Institution	Kanazawa University
Principal Investigator	UEDA TERUYUKI 金沢大学, 医学系, 協力研究員 (80600741)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	肝細胞癌 / ウイルス性肝疾患 / 遺伝子発現解析
Research Abstract	DNA damage response genes in non-tumor lesions were associated with AP1 signaling which mediates the expression of many genes in CH-B-related HCC. In contrast, signal transducers and activators of transcription 1 and phosphatase and tensin homolog in non-tumor lesions were associated with early growth response protein 1 signaling that potentially promotes angiogenesis, fibrogenesis, and tumorigenesis in CH-C-related HCC. MicroRNAs were up- or down-regulated in cancerous tissue. These expression changes were confirmed as previously. Gene expression profiling of HCC and non-tumor lesions revealed the predisposing changes of gene expression in HCC. This approach has potential for the early diagnosis and possible prevention of HCC.