2014 Fiscal Year Final Research Report
Clarification of Mechanism of Anti-microRNA-122 Therapy for Hepatitis C Virus Infection
| Project/Area Number |
24790687
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | C型肝炎ウイルス / microRNA-122 / C型慢性肝炎 / 抗ウイルス療法 |
|---|
| Outline of Final Research Achievements |
The emergence of Direct-Acting Antiviral Agents (DAA)-resistant virus could be a serious problem for the treatment of chronic hepatitis C patients. We examined the efficiency of the combination therapy with DAA and anti-miR-122 therapy, which is targeting liver-specific miRNA, miR-122. We demonstrated that the combination therapy (1) shows synergistic antiviral effect, (2) alleviates the drug resistance of DAA-resistance viruses, and (3)completely inhibits the emergence of DAA-resistance virus. These results indicate that anti-miR-122 therapy is quite useful in terms of inhibiting the emergence of DAA-resistance virus when it is combined with DAA.
|
| Free Research Field |
消化器内科学
|
