2013 Fiscal Year Final Research Report
A Research for an immunotherapy combined with chemotherapy for patients with advanced solid tumors.
| Project/Area Number |
24790708
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 腫瘍免疫学 / 細胞傷害性T細胞 / RNF43 / 免疫寛容 / 臨床試験 / 樹状細胞 / 癌 |
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| Research Abstract |
Ten patients with advanced solid tumors were completed with the clinical trial. None of the patients suffered from severe adverse events. Clinical responses at 4 and 7 weeks after the treatment respectively showed that 9 and 5 patients were in stable disease (SD), and 1 and 4 patients were in progress disease (PD). The frequency of circulating regulatory T cells (Treg) significantly decreased after cyclophosphamide (CPM), and the higher decreasing rate of Treg was related with good clinical response. The positive response rate of RNF43-specific circulating T cells significantly increased in SD cases. Higher levels of serum IL-6 and IL-10 prior to the treatment were observed in PD cases. In conclusion, the combination of immunotherapy and CPM was tolerable, and may induce tumor specific immune responses accompanied by the reduction of Tregs and be efficient against advanced solid tumors. Both of IL-6 and IL-10 are considered to be good biomarkers to predict clinical response in advance.
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Research Products
(14 results)
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[Journal Article] TLR7 Ligand Augments GM-CSF-Initiated Antitumor Immunity through Activation of Plasmacytoid Dendritic Cells2014
Author(s)
Narusawa M, Inoue H,Matsumura Y,Takahashi A, Inoue T, Watnabe A, Miyamoto S,Miura Y, Hijikata Y, Tanaka Y, Inoue M, Takayama K, Okazaki T, Hasegawa M, Nakanishi Y, Tani K
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Journal Title
Cancer Immunol Res
Volume: 2(6)
Pages: 1-13
DOI
Peer Reviewed
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[Journal Article] Development of novel immune therapies for solid tumors : phase I clinical trials in a single institute2012
Author(s)
Hijikata Y, Murahashi -Iga M, Okazaki T, Tanaka Y, Odaira K, Okano S, Hisano T, Takahashi A, Marumoto T, Inoue H, Tani K
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Journal Title
Rinsho Ketsueki
Volume: 53(5)
Pages: 487-92
DOI
Peer Reviewed
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[Journal Article] Absence of LTB4/BLT1 axis facilitates generation of mouse GM-CSF-induced long-lasting antitumor immunologic memory by enhancing innate and adaptive immune systems2012
Author(s)
Yokota Y, Inoue H, Matsumura Y, Nabeta H, Narusawa M, Watanabe A, Sakamoto C, Hijikata Y, Iga-Murahashi M, Takayama K, Sasaki F, Nakanishi Y, Yokomizo T
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Journal Title
Tani K.Blood
Volume: 120(17)
Pages: 3444-54
DOI
Peer Reviewed
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