2013 Fiscal Year Final Research Report
Epigenetic Analysis of macrophage activation
| Project/Area Number |
24790741
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ISAGAWA Takayuki 東京医科歯科大学, 難治疾患研究所, 助教 (40418637)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | macrophage / inflammation / NFkB / metabolism |
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| Research Abstract |
It is well known that chronic inflammation forms the basis of cancers and the metabolic syndrome. Therefore, in the present study, we performed a comprehensive, genome-wide examination of the targets of NFkBs, the central transcriptional regulator of inflammation, in the context of regulatory mechanisms of inflammation in macrophages. As a result, we revealed that NFkB subunit switching occurs during the transition from the inflammatory response phase to the resolution phase. Furthermore, we found that p50, a NFkB subunit, regulates inflammatory genes during the early inflammatory phase but then shifts to regulating metabolic genes during the resolution phase. We also revealed that p50 is involved in the metabolic reprogramming associated with the inflammatory response.
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[Journal Article] Growth differentiation factor-15 is a useful prognostic marker in patients with heart failure with preserved ejection fraction.2014
Author(s)
Izumiya Y, Hanatani S, Kimura Y, Takashio S, Yamamoto E, Kusaka H, Tokitsu T, Rokutanda T, Araki S, Tsujita K, Tanaka T, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Ogawa H
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Journal Title
Can J Cardiol
Volume: 30
Pages: 338-44
Peer Reviewed
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[Journal Article] Circulating thrombospondin-2 reflects disease severity and predicts prognosis of patients with heart failure with reduced ejection fraction2014
Author(s)
Hanatani S, Izumiya Y, Takashio S, Kimura Y, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Ogawa H
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Journal Title
Circ J
Volume: 78
Pages: 903-10
Peer Reviewed
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[Journal Article] Growth differentiation factor 15 can distinguish between hypertrophic cardiomyopathy and hypertensive hearts2014
Author(s)
Hanatani S, Izumiya Y, Takashio S, Kojima S, Yamamuro M, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H
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Journal Title
Heart Vessels
Volume: 29
Pages: 231-7
Peer Reviewed
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