2013 Fiscal Year Annual Research Report
冠動脈硬化の基盤となる冠攣縮性狭心症患者の冠動脈プラーク組織性状評価
Project/Area Number |
24790769
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Research Institution | Kumamoto University |
Principal Investigator |
辻田 賢一 熊本大学, 医学部附属病院, 助教 (60571263)
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Keywords | 冠攣縮 / 血管内超音波 / 冠動脈プラーク / 組織性状 |
Research Abstract |
1.予後調査:平成24年度の計画において、本研究に登録された対象患者の心血管イベントを含めた予後調査を施行。具体的には、外来主治医もしくは紹介元へのアンケートおよび患者への電話連絡にて主要心血管有害事象(①心臓死、②非致死性Q波あるいは非Q波心筋梗塞、③経皮的冠動脈形成術あるいはCABGの施行)の有無を確認し、これらの心血管イベント発生と冠動脈プラーク組織性状および冠動脈プラーク容積などの3次元解析データとの相関を検討。結果、冠攣縮性狭心症患者においては、びまん性の内膜肥厚があるにもかかわらず、予後良好であることが示唆された。 2.フォローアップ患者におけるIVUS・冠動脈プラーク組織性状評価法・3次元解析の施行:冠動脈インターベンション後の確認造影検査などでフォローアップの心臓カテーテル検査が施行しえた症例において、IVUS記録および冠動脈プラーク組織性状評価法を再施行した。冠攣縮性狭心症患者においても、至適薬物治療が行われれば、冠動脈プラーク進展(動脈硬化進展)は極めて軽度であることが示された。 3.血管内皮機能検査・酸化ストレスマーカー測定のフォローアップ:前述の内皮機能検査Endo-PATやThioredoxinや8-OHdGなど酸化ストレスマーカーをフォローアップ患者において測定した。至適薬物治療によって、冠攣縮性狭心症患者においても内皮機能の改善が得られることが明らかになった。
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Author(s)
Hanatani S, Izumiya Y, Takashio S, Kojima S, Yamamuro M, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
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[Journal Article] Growth differentiation factor-15 is a useful prognostic marker in patients with heart failure with preserved ejection fraction.2014
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Can J Cardiol
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[Journal Article] Circulating thrombospondin-2 reflects disease severity and predicts outcome of heart failure with reduced ejection fraction.2014
Author(s)
Hanatani S, Izumiya Y, Takashio S, Kimura Y, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Ogawa H.
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[Journal Article] Serial intravascular ultrasound assessment of very late stent thrombosis after sirolimus-eluting stent placement.2014
Author(s)
Yamanaga K, Tsujita K, Shimomura H, Nakamura Y, Ogura Y, Onoue Y, Chazono N, Nagata T, Morisaki S, Kudo T, Yamada Y, Komura N, Miyazaki T, Akasaka T, Horio E, Sato K, Arima Y, Kojima S, Kaikita K, Tayama S, Hokimoto S, Ogawa H.
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Journal Title
J Cardiol
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[Journal Article] Correlation Between Extent of Myocardial Fibrosis Assessed by Cardiac Magnetic Resonance and Cardiac Troponin T Release in Patients With Nonischemic Heart Failure.2014
Author(s)
Takashio S, Yamamuro M, Uemura T, Utsunomiya D, Morita K, Izumiya Y, Sugiyama S, Kojima S, Yamamoto E, Tsujita K, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Yasuda O, Yamashita Y, Ogawa H.
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Am J Cardiol
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[Journal Article] Coronary microvascular dysfunction and diastolic load correlate with cardiac troponin T release measured by a highly sensitive assay in patients with nonischemic heart failure.2013
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Takashio S, Yamamuro M, Izumiya Y, Sugiyama S, Kojima S, Yamamoto E, Tsujita K, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Ogawa H.
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J Am Coll Cardiol
Volume: 62
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DOI
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[Journal Article] Coronary vasomotor response to intracoronary acetylcholine injection, clinical features, and long-term prognosis in 873 consecutive patients with coronary spasm: analysis of a single-center study over 20 years.2013
Author(s)
Sato K, Kaikita K, Nakayama N, Horio E, Yoshimura H, Ono T, Ohba K, Tsujita K, Kojima S, Tayama S, Hokimoto S, Matsui K, Sugiyama S, Yamabe H, Ogawa H.
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Journal Title
J Am Heart Assoc
Volume: 2
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DOI
Peer Reviewed
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[Presentation] Impaired Peripheral Endothelial Function as Assessed by Digital Reactive Hyperemia Peripheral Arterial Tonometry and Risk of In-Stent Restenosis.2013
Author(s)
Komura N, Tsujita K, Yamanaga K, Kaikita K, Hokimoto S, Iwashita S, Miyazaki T, Akasaka T, Sato K, Horio E, Yoshimura H, Arima Y, Kojima S, Tayama S, Nakamura S, Sugiyama S, Hibi K, Kimura K, Umemura S, Ogawa H.
Organizer
86th American Heart Association Scientific Sessions
Place of Presentation
Dallas, TX, USA
Year and Date
20131116-20131120
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[Presentation] Single-Wire Pressure and Flow Velocity Measurement to Quantify Microvascular Dysfunction in Patients With Coronary Vasospastic Angina.2013
Author(s)
Yamanaga K, Tsujita K, Komura N, Kaikita K, Hokimoto S, Miyazaki T, Saito M, Akasaka T, Sato K, Horio E, Yoshimura H, Arima Y, Kojima S, Tayama S, Nakamura S, Ogawa H.
Organizer
86th American Heart Association Scientific Sessions
Place of Presentation
Dallas, TX, USA
Year and Date
20131116-20131120
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[Presentation] Impact of Acetylcholine-provoked Diffuse Coronary Spasm on Clinical Features and Long-term Prognosis of Patients With Coronary Spasm.2013
Author(s)
Sato K, Kaikita K, Yoshimura H, Nakayama N, Horio E, Ohba K, Tsujita K, Tayama S, Hokimoto S, Matsui K, Sugiyama S, Yamabe H, Ogawa H.
Organizer
86th American Heart Association Scientific Sessions
Place of Presentation
Dallas, TX, USA
Year and Date
20131116-20131120
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[Presentation] Association between Abnormal Glucose Metabolism and Coronary Hyper-perfusion in Normal Coronary Patients Without Ischemic Heart Disease.2013
Author(s)
Fujisue K, Ohba K, Sugiyama S, Matsubara J, Nozaki T, Kurokawa H, Maeda H, Sumida H, Nagayoshi Y, Sakamoto K, Yamamoto E, Tsujita K, Hokimoto S, Ogawa H.
Organizer
86th American Heart Association Scientific Sessions
Place of Presentation
Dallas, TX, USA
Year and Date
20131116-20131120
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[Presentation] Acetylcholine-Provoked Myocardial Lactate Production is Frequently Observed in Non-smoking Female Patients With Multivessel Coronary Spasm.2013
Author(s)
Kaikita K, Sato K, Nakayama N, Horio E, Yoshimura H, Tsujita K, Kojima S, Tayama S, Hokimoto S, Ogawa H.
Organizer
86th American Heart Association Scientific Sessions
Place of Presentation
Dallas, TX, USA
Year and Date
20131116-20131120
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[Presentation] Impact of Balloon Pulmonary Angioplasty on Chronic Thromboembolic Pulmonary Hypertension Complicated With Homocystinuria.2013
Author(s)
Katayama T, Ogawa S, Kaikita K, Tsukamoto M, Yamamoto E, Yamamuro M, Tanaka T, Tsujita K, Kojima S, Tayama S, Hokimoto S, Yamabe H, Indo Y, Endo F, Matsubara H, Ogawa H.
Organizer
86th American Heart Association Scientific Sessions
Place of Presentation
Dallas, TX, USA
Year and Date
20131116-20131120
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