Effects of ADMA and Light Exposure on Melatonin-Related Blood Pressure Variability

2014 Fiscal Year Final Research Report

• Project/Area Number: 24790774
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Nara Medical University
• Principal Investigator: OBAYASHI Kenji 奈良県立医科大学, 医学部, 助教 (30596656)
• Research Collaborator: SAEKI Keigo 奈良県立医科大学, 医学部医学科, 講師 (60364056) ; TONE Nobuhiro 奈良県立医科大学, 医学部医学科, 特任助手 (50630498)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: メラトニン / ADMA / 夜間血圧 / 交互作用 / サーカディアンリズム / 生体リズム / 光曝露 / 疫学

Outline of Final Research Achievements

Background: Melatonin decreases nighttime blood pressure (BP) by increasing nitric oxide (NO) in endothelial cells. Whether serum asymmetric dimethylarginine (ADMA), a major endogenous competitive inhibitor of endothelial NO synthase, attenuates the association of melatonin with nighttime BP is unclear.
Methods and Results: Serum ADMA, urinary 6-sulfatoxymelatonin excretion (UME), and ambulatory BP were measured in 852 elderly individuals. In the low-ADMA group (n=451), higher UME was inversely associated with adjusted odds ratio for nocturnal hypertension and non-dipper (Q1, 1.00 and 1.00; Q2, 0.92 and 0.74; Q3, 0.57 and 0.51; Q4, 0.48 and 0.40; P=0.004 and 0.002, respectively) but not in the high-ADMA group (n=401) (P=0.75 and 0.12, respectively). These trends were also observed on continuous variable analysis (low ADMA, P=0.031 and 0.003; high ADMA, P=0.52 and 0.13; respectively).
Conclusions: ADMA attenuates the association of endogenous melatonin with night-time BP and dipping.

Free Research Field

疫学