Establishment of analysis method of HDL function and its clinical application

2013 Fiscal Year Final Research Report

• Project/Area Number: 24790789
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Fukuoka University
• Principal Investigator: IMAIZUMI Satoshi 福岡大学, 医学部, 講師 (60609478)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: HDL機能 / コレステロール引き抜き能 / 抗酸化能

Research Abstract

The major findings of our study are that the cholesterol efflux capacity but not anti-oxidative capacity of HDL was significantly associated with in-stent late loss after stent implantation, and that compared with patients with the higher efflux capacity, patients with the lower efflux capacity demonstrated increased risk of higher in-stent late loss.
We also found that smoking cessation leads to the improvement of HDL functionality (cholesterol efflux capacity and anti-oxidative capacity) without changing HDL-C, apoA-I levels and HDL subfractions.

Research Products

• [Presentation] Impact of Cigarette Smoking Cessation on HDL Functionality. (2014)
  • Author(s): Imaizumi S, Miura S, Takata K, Zhang B, Uehara Y, Saku K
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Tokyo.
  • Year and Date: 20140321-23
• [Presentation] Impact of Cigarette Smoking Cessation on HDL Functionality (2014)
  • Author(s): 高田耕平、今泉聡、川内絵未、末松保憲、張波、塚原ひとみ、野田慶太、八尋英二、上原吉就、三浦伸一郎、朔啓二郎
  • Organizer: 第10回西日本血管・機能研究会
  • Place of Presentation: 福岡
  • Year and Date: 2014-08-09
• [Presentation] Relation between HDL Function and Inflammatory/Metabolic Markers in Patients with Coronary Artery Disease (CAD). (2013)
  • Author(s): Takata K, Imaizumi S, Miura S, Takamiya Y, Fukuda Y, Kawamura A, Zhang B, Iwata A, Nishikawa H, Matsuo K, Shirai K, Uehara Y, Reddy ST, Saku K.
  • Organizer: The 77th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Yokohama.
  • Year and Date: 20130315-17
• [Presentation] High-Density Lipoprotein Functionality Could Be a Novel Marker for Predicting Coronary Artery Remodeling. (2013)
  • Author(s): Suematsu Y, Iwata S, Takata K, Imaizumi S, Miura S, Saku K
  • Organizer: The 77th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Yokohama.
  • Year and Date: 20130315-17
• [Presentation] High-Density Lipoprotein Functionality Could Be a Novel Marker for Predicting Coronary Artery Remodeling. merican College of Cardiology (ACC) (2013)
  • Author(s): Iwata S, Imaizumi S, Miura S, Saku K
  • Organizer: 2013 Scientific Sessions
  • Place of Presentation: San Francisco, California.
  • Year and Date: 20130309-11
• [Presentation] 冠動脈病変とHDL機能との関連 (2013)
  • Author(s): 今泉聡、三浦伸一郎、高田耕平、岩田敦、朔啓二郎
  • Organizer: 第8回高血圧と冠動脈疾患研究会
  • Year and Date: 2013-12-21
• [Presentation] Association between HDL functionality and coronary restenosis after stent implantation. (2013)
  • Author(s): Satoshi Imaizumi, Shin-Ichiro Miura, Yosuke Takamiya, Akira Kawamura, Bo Zhang, Atsushi Iwata, Hiroaki Nishikawa, Kunihiro Matsuo, Kazuyuki Shirai, Yoshinari Uehara, Keijiro Saku
  • Organizer: 第7回 Cardio-Diabetes研究会
  • Place of Presentation: 東京
  • Year and Date: 2013-02-23
• [Presentation] HDL Functionality could be a Novel Marker for Predicting Restenosis after Stent Implantation. (2012)
  • Author(s): Satoshi Imaizumi, Shin-Ichiro Miura, Yosuke Takamiya, Akira Kawamura, Bo Zhang, Atsushi Iwata, Hiroaki Nishikawa, Kunihiro Matsuo, Kazuyuki Shirai, Yoshinari Uehara, Srinivasa T. Reddy, Keijiro Saku
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Los Angeles, California.
  • Year and Date: 20121103-07
• [Presentation] HDL Functionality Could Be a Novel Marker for Predicting Restenosis after Stent Implantation. ISHR (2012)
  • Author(s): Imaizumi S, Miura S, Takamiya Y, Uehara Y, Reddy ST, Saku K
  • Organizer: International Society for Heart Research
  • Place of Presentation: Yokohama.
  • Year and Date: 20121026-27
• [Presentation] ステント内再狭窄の新たな予測因子としてのHDL機能の可能性 (2012)
  • Author(s): 今泉聡、三浦伸一郎、朔啓二郎
  • Organizer: 第113回日本循環器学会九州地方会
  • Place of Presentation: 熊本
  • Year and Date: 2012-12-08