2014 Fiscal Year Final Research Report
Significance of tissue progenitor cells in progression of lung fibrosis and immunological depletion of progenitor cells
| Project/Area Number |
24790806
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 組織幹細胞 / 間質性肺炎 / 線維化 / 分化 |
|---|
| Outline of Final Research Achievements |
This investigation was performed following the hypothesis that abnormal differentiation of tissue stem cells might be one of the development mechanisms of lung fibrosis.
Creating the mice model which tissue stem cells were depleted immunologicaly. Extracting the tissue stem cells from lung, after apoptosis was induced, it was administered to antigen presenting cells (APC) differentiated from mice bone marrow cells. APCs were administered to mice, then interstitial pneumonia was induced by bleomysine. High mortality rate and delayed recovery from inflammation were revealed in these mice.
|
| Free Research Field |
呼吸器内科学
|
