2014 Fiscal Year Final Research Report
Development of pleural mesothelioma treatment targeting for cancer-associated fibroblasts
| Project/Area Number |
24790815
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Kagawa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 悪性胸膜中皮腫 / 線維芽細胞 |
|---|
| Outline of Final Research Achievements |
Most cases of malignant pleural mesothelioma are inoperable, and have poor prognosis when they are chemotherapy-resistance. Recently, cancer-associated fibroblasts (CAF) had been reported, that are observed around cancer cells and have a role on cancer progression. In this study, association between malignant pleural mesothelioma cells and fibroblasts were investigated.
Cell migration was assessed by chemotaxis, and cell invasion was assessed by Matrigel invasion assay. The culture media derived from lung fibroblasts augmented magratory and invasive abilities of malignant pelural mesothelioma cells. Exogenous fibronectin and hepatocyte growth factor (HGF) augmented mesothelioma cell migration and invasion, respectively. It was found that fibronectin and HGF were released from lung fibroblasts.
|
| Free Research Field |
呼吸器内科
|
