Dysfunction of HDL and macrophages in kidney disease-accelerated atherosclerosis and the therapeutic strategy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24790837
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Niigata University
• Principal Investigator: YAMAMOTO Suguru 新潟大学, 医歯(薬)学総合研究科, 特任助教 (70444156)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 慢性腎臓病 / 動脈硬化 / 心血管病 / HDLコレステロール / マクロファージ / インドキシル硫酸

Outline of Final Research Achievements

Purpose of the study is to elucidate the mechanism of dysfunction of macrophage and HDL cholesterol in kidney disease-accelerated atherosclerosis. HDL isolated from kidney disease patients induced macrophage inflammation and abnormal lipid metabolism. Indoxyl sulfate also induced macrophage inflammation and abnormal lipid metabolism. Those results indicate that indoxyl sulfate may induce dysfunctions of macrophage and HDL, and the intervention to them will be an attractive therapeutic strategy for kidney disease-accelerated atherosclerosis.

Free Research Field

腎臓病学