2013 Fiscal Year Final Research Report
Development of procine model to establish the specific treatment for IgA nephropathy
| Project/Area Number |
24790859
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Research Collaborator |
SUZUKI Yusuke 順天堂大学, 医学部, 准教授 (70372935)
MUTO Masahiro 順天堂大学, 医学部, 大学院生
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | IgA腎症モデル豚 / 口蓋扁桃摘出術 / 腎生検 / APRIL |
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| Research Abstract |
Though immunological disorders in mucosa with a focus on tonsils are suggested to be involved in the pathogenesis of human IgA nephropathy (IgAN), there are no appropriate animal models bearing tonsils. Since it was reported that porcine develop spontaneous renal lesions resembling human IgAN in addition to bearing tonsils, we focused on porcine as a novel animal models of IgAN. After we confirmed that micro-minipigs (MMPs) develop spontaneous renal lesions resembling human IgAN as well as other types of porcine, we started to compare the phenotype containing renal lesions between MMPs in the natural course group (natural course G) and those in the tonsillectomy group (tonsillectomy G). Immunofluorescence stainings indicated that the intensity of glomerular deposition of immunogloblin containing IgA in MMPs of tonsillectomy G may be lower than that of natural course G at eight months old. Now we are continuing the comparison of phenotype with a focus on renal lesions.
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