The relationship between sympathetic nerve activity and blood pressure of chronic intermittent hypoxia

2013 Fiscal Year Final Research Report

• Project/Area Number: 24790863
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Nihon University
• Principal Investigator: OGURA SAYOKO 日本大学, 医学部, 助手 (30618202)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 高血圧 / ストレス / 生理学 / 間欠的低酸素

Research Abstract

The Sleep Apnea Syndrome (SAS) patients are twice as high incidence of hypertension compared with those who are not SAS. However, i the mechanism is for the onset of hypertension is not clear. The experiments were carried out with the aim in particular, to clarify the change in Na reabsorption in the kidney and sustained sympathetic activation by intermittent hypoxia. Blood pressure was not altered by intermittent hypoxia under normal diet, however, it was significantly elevated by high salt diet. The catecholamine contents in several organs were also increased. It is possible that sympathetic nerve activity is enhanced by the intermittent hypoxia and it.might contribute to development of salt sensitive hypertension.

Research Products

• [Journal Article] Oxidative stress augments pulmonary hypertension in chronically hypoxic mice overexpressing oxidized LDL receptor (2013)
  • Author(s): Ogura S, Shimosawa T, Mu S, Sonobe T, Kawakami-Mori F, Wang H, Uetake Y, Yoshida KI, Yatomi Y, Shirai M, Fujita T
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 305 Pages: H155-62
  • Peer Reviewed
• [Journal Article] Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart (2013)
  • Author(s): Hideyuki Maeda, Hisashi Nagai, Genzou Takemura, Kaori Shintani-Ishida, Masaaki Komatsu, Sayoko Ogura, Toshihiko Aki, Mikiayasu Shirai, Ichiro Kuwahira, Ken-ichi Yoshida
  • Journal Title: Biochimica et Biophysica Acta Molecular biology of disease Volume: 1832 Pages: 1159-1166
  • Peer Reviewed
• [Journal Article] LOX-1 in atherosclerosis : biological functions and pharmacological modifiers (2013)
  • Author(s): Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  • Journal Title: Cell Mol Life Sci. Volume: 70 Pages: 2859-2872
  • Peer Reviewed
• [Journal Article] Oxidative Stress in Multiple Organ Damage in Hypertension, Diabetes and CKD, Mechanisms and New Therapeutic Possibilities (2012)
  • Author(s): Shimosawa T, Kaneko T, Qingyou X, Miyamoto Y, Shengyu M, Wang H, Ogura S, Jimbo R, Majtan B, Uetake Y, Hirohama D, Kawakami-Mori F, Fujita T and Yatomi Y
  • Journal Title: Oxidative Stress and Diseases Pages: 978-953-51-0552-7
• [Journal Article] Tanshirone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation (2012)
  • Author(s): Suowen Xu, Zhiping Liu, Yan Huang, Kang Le, Futian Tang, Heqing Huang, Sayoko Ogura, Peter J. Little, Xiaoyan Shen, Peiqing Liu
  • Journal Title: Translational Research Volume: 160 Pages: 114-24
  • Peer Reviewed
• [Journal Article] 内分泌学からみた血圧調節のメカニズム (2012)
  • Author(s): 小倉彩世子、下澤達雄
  • Journal Title: インスリン内分泌・糖尿病・代謝内科 Volume: 35 Pages: 432-436
• [Presentation] 放射光をもちいた間欠的低酸素および糖尿病モデルラットにおける心血管の病態解析 (2013)
  • Author(s): 小倉彩世子、白井幹康、永井恒志、奈良明奈、桑平一郎、下澤達雄、吉田謙一
  • Organizer: 第17回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2013-11-23
• [Presentation] 急性食塩負荷時の交感神経活動の変化 LF/HFでの評価 (2013)
  • Author(s): 下澤達雄,小倉彩世子,宿谷賢一,田中雅美,矢冨裕
  • Organizer: 第60回日本臨床検査医学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2013-11-03
• [Presentation] ファブリー病スクリーニングにおけるE66Q変異と腎組織像 (2013)
  • Author(s): 里村厚司,藤田宜是,永島正明,小倉彩世子,荒島康友 ,星野忠,志方えりさ,藤岡和美,土屋達行,中山智祥
  • Organizer: 第60回日本臨床検査医学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2013-11-03
• [Presentation] 血中CRP複合体測定についての検討 (2013)
  • Author(s): 小倉彩世子、土屋達行、里村厚司、永島正明、星野忠、荒島康友、志方えりさ、藤岡和美、下澤達雄、中山智祥
  • Organizer: 第60回日本臨床検査医学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2013-11-02
• [Presentation] 妊娠時ストレスが胎児の発達後血圧に与える影響 (2013)
  • Author(s): 森典子、神保りか、広浜大五郎、Latapati Lehman、小倉彩世子、渡辺大輔、安藤孝、関康史、吉田尚弘、森本聡、市原淳弘、下澤達雄
  • Organizer: 第36回日本高血圧学会
  • Place of Presentation: 大阪
  • Year and Date: 2013-10-25
• [Presentation] 高血圧患者での急性食塩負荷時の交感神経活動の変化 LF/HFでの評価 (2013)
  • Author(s): 下澤達雄、小倉彩世子、森典子、広浜大五郎、Reheman Latapati、神保りか、上竹勇三郎
  • Organizer: 第36回日本高血圧学会
  • Place of Presentation: 大阪
  • Year and Date: 2013-10-25
• [Presentation] 腎除神経術は降圧非依存的に心拡張障害を軽減させる (2013)
  • Author(s): 広浜大五郎、森典子、小倉彩世子、穆勝宇、神保りか、上竹勇三郎、藤田敏郎、南学正臣、下澤達雄
  • Organizer: 第36回日本高血圧学会
  • Place of Presentation: 大阪
  • Year and Date: 2013-10-25
• [Presentation] 放射光をもちいた間欠的低酸素および糖尿病モデルラットにおける心血管の病態解析 (2013)
  • Author(s): 小倉彩世子、白井幹康、永井恒志、奈良明奈、桑平一郎、下澤達雄、中山智幸、吉田謙一
  • Organizer: 第36回日本高血圧学会
  • Place of Presentation: 大阪
  • Year and Date: 2013-10-24
• [Presentation] 急性食塩負荷時の自律神経の変化 (2013)
  • Author(s): 下澤達雄、広浜大五郎、小倉彩世子、森典子、神保りか、Rcheman Latapati,上竹勇三郎
  • Organizer: 第2回臨床高血圧フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2013-05-25
• [Presentation] Oxidative stress augments pulmonary hypertension in chronically hypoxic mice overexpressing oxidized LDL receptor (2013)
  • Author(s): 小倉彩世子、下澤達雄、永井恒志、吉田謙一
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-15
• [Presentation] 維持透析療法中の慢性腎不全患者における機能的マンノース結合レクチンを含めた各種生命予後の検討 (2012)
  • Author(s): 里村厚司、藤田宜是、永島正明、小倉彩世子、荒島康友、星野忠、土屋達行、中山智祥
  • Organizer: 第59回日本臨床検査医学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-11-30
• [Presentation] 血中 CRP複合体測定についての基礎的検討 (2012)
  • Author(s): 小倉彩世子、土屋達行、里村厚志、永島正明、星野忠、荒島康友、下澤達雄、中山智祥
  • Organizer: 第59回日本臨床検査医学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-11-29
• [Presentation] Strict fluid management prevented left ventricular hypertrophy in long-term peritoneal dialysis patients (2012)
  • Author(s): Daigoro Hirohama, Tatsuo Shimosawa, Yoshitaka Ishibashi, Shengyu Mu, Fumiko Kawakami-Mori, Rika Jimbo, Sayoko Ogura, Yuzaburo Uetake, Yohei Takara, Satoshi Kinugasa, Toshiro Fujita
  • Organizer: 24th Scientific Meeting of International Society of Hypertension
  • Place of Presentation: Sydney
  • Year and Date: 2012-09-30