2014 Fiscal Year Final Research Report
Mitochondrial dysfunction in familial Parkinson's disease.
| Project/Area Number |
24790903
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | 防衛大学校(総合教育学群、人文社会科学群、応用科学群、電気情報学群及びシステム工学群) |
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Principal Investigator |
AMO Taku 防衛大学校(総合教育学群、人文社会科学群、応用科学群、電気情報学群及びシステム工, 応用科学群, 助教 (40453922)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | パーキンソン病 / ミトコンドリア |
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| Outline of Final Research Achievements |
Mitochondrial dysfunction is a hallmark of both idiopathic and familial Parkinson's disease (PD). In this study, detailed analysis of mitochondrial dysfunction caused by loss of PINK1 revealed both of mitochondrial Complex I and III deficiencies. Recently, CHCHD2 was identified as a novel causative gene in mendelian forms of Parkinson’s disease. In this study, it was shown that CHCHD2 was localized in mitochondrial intermembrane space.
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| Free Research Field |
生化学
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