Finding of the overeating mechanism and the therapeutic strategy of obesity by new approach from reward circuit.

2013 Fiscal Year Final Research Report

• Project/Area Number: 24790943
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: Keio University (2013); Kyoto University (2012)
• Principal Investigator: YAMADA Nobuko 慶應義塾大学, 医学部, 特任助教 (50400891)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 肥満 / 高脂肪食 / 報酬系 / 過食 / 食事性肥満モデル / 摂食調節 / 視床下部 / 慢性炎症

Research Abstract

To elucidate the mechanism of overeating in human obesity, we analyzed regulatory system of food intake in the mice brain. We used mice fed on a high-fat diet.
Mice fed on a high-fat diet for 2 weeks gained more weight and visceral fat compared with control mice. Still they did not show any increment of blood glucose levels. With modification by fasting and fasting-refeeding, mice fed on a high-fat diet exhibited many differences in gene expressional patterns and responses to drug administration. These changes were observed in several nucleus in the brain suggesting that there might be common underline mechanism.

Research Products

• [Journal Article] Intracerebroventricular administration of C-Type natriuretic peptide suppresses food intake via activation of the melanocortin system in mice (2013)
  • Author(s): Yamada-Goto N, Katsuura G, Ebihara K, Inuzuka M, Ochi Y, Yamashita Y, Kusakabe T, Yasoda A, Satoh-Asahara N, Ariyasu H, Hosoda K, Nakao K
  • Journal Title: Diabetes Volume: 62 Pages: 1500-1504
  • DOI: 10.2337/db12-0718
  • Peer Reviewed
• [Journal Article] An approach toward CNS dysfunction associated with metabolic syndrome; implication of leptin, which is a key molecule of obesity, in depression associated with obesity (2012)
  • Author(s): Yamada-Goto N, Katsuura G, Ochi Y, Nakao K
  • Journal Title: Nihon Shinkei Seishin Yakurigaku Zasshi Volume: 32 Pages: 245-250
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/23373
• [Journal Article] Impairment of fear-conditioning responses and changes of brain neurotrophic factors in diet-induced obese mice (2012)
  • Author(s): Yamada-Goto N, Katsuura G, Ochi Y, Ebihara K, Kusakabe T, Hosoda K, Nakao K
  • Journal Title: J Neuroendocrinol Volume: 24 Pages: 1120-1125
  • DOI: 10.1111/j.1365-2826.2012.02327.x
  • Peer Reviewed
• [Journal Article] Salivary cortisol levels are associated with outcomes of weight reduction therapy in obese Japanese patients (2012)
  • Author(s): Himeno A, Satoh-Asahara N, Usui T, Wada H, Tochiya M, Kono S, Yamada-Goto N, Katsuura G, Hasegawa K, Nakao K, Shimatsu A
  • Journal Title: Metabolism Volume: 61 Pages: 255-261
  • DOI: 10.1016/j.metabol.2011.06.023
  • Peer Reviewed
• [Presentation] 脳特異的NPR- B欠損マウスの肝臓および内臓脂肪への脂質蓄積抑制効果 (2013)
  • Author(s): 山下唯, 後藤伸子, 勝浦五郎, 宮崎由理, 今吉格, 金本巨哲, 三浦晶子, 八十田明宏, 荒井宏司, 細田公則, 大日向耕作, 影山龍一郎, 中尾一和
  • Organizer: 第17回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 20131122-23
• [Presentation] 脳特異的NPR-B欠損マウスにおける内臓脂肪蓄積および脂肪肝進展抑制効果 (2013)
  • Author(s): 山下唯, 後藤伸子, 勝浦五郎, 宮崎由理, 今吉格, 金本巨哲, 三浦晶子, 八十田明宏, 荒井宏司, 細田公則, 大日向耕作, 影山龍一郎, 中尾一和
  • Organizer: 第34回日本肥満学会
  • Place of Presentation: 東京
  • Year and Date: 20131011-12
• [Presentation] New insight into mental disorders associated with obesity : Possible involvement of leptin and amylin (2013)
  • Author(s): 後藤伸子, 伊藤裕
  • Organizer: 第10回インスリン抵抗性とメタボリックシンドローム研究会
  • Place of Presentation: 東京
  • Year and Date: 20130706-07
• [Presentation] Brain NPR-B deficiency attenuates high-fat diet-induced hepatic steatosis in mice (2013)
  • Author(s): Yui Yamashita, Nobuko Yamada-Goto, Goro Katsuura, Yukari Ochi, Yuri Miyazaki, Itaru Imayoshi, Hiroyuki Ariyasu, Naotetsu Kanamoto, Masako Miura, Akihiro Yasoda, Hiroshi Arai, Kousaku Ohinata, Ryoichiro Kageyama, Kazuwa Nakao
  • Organizer: The Endocrine Society's 95th Annual Meeting & Expo
  • Place of Presentation: San Francisco
  • Year and Date: 20130615-18
• [Presentation] 脂肪肝病態形成における中枢CNP/GC-Bシグナルの役割-高脂肪食負荷脳特異的GC-B欠損マウスによる検討 (2013)
  • Author(s): 山下唯, 後藤伸子, 勝浦五郎, 宮崎由理, 今吉格, 金本巨哲, 三浦晶子, 八十田明宏, 大日向耕作, 影山龍一郎, 稲垣暢也, 中尾一和
  • Organizer: 第86回日本内分泌学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 20130524-26
• [Presentation] 脳特異的GC-B deficientマウスの脂肪肝改善作用の検討 (2013)
  • Author(s): 山下唯, 後藤伸子, 勝浦五郎, 越智ゆかり, 今吉格, 有安宏之, 金本巨哲, 三浦晶子, 八十田明宏, 荒井宏司, 影山龍一郎, 中尾一和
  • Organizer: 第86回日本内分泌学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 20130425-27
• [Presentation] 脳特異的GC-B欠損マウスを用いたCNP/GC-B系の中枢性エネルギー代謝調節に及ぼす作用の解析 (2012)
  • Author(s): 山下 唯, 後藤 伸子, 勝浦 五郎, 越智 ゆかり, 有安 宏之, 金本 巨哲, 三浦 晶子, 海老原 健, 八十田 明宏, 荒井 宏司, 細田 公則, 中尾 一和
  • Organizer: 第33回日本肥満学会
  • Place of Presentation: 京都市
  • Year and Date: 20121011-12
• [Presentation] 高脂肪食負荷による絶食後再摂食の反応とオピエイト受容体アンタゴニストの作用 (2012)
  • Author(s): 後藤 伸子, 越智 ゆかり, 勝浦 五郎, 山下 唯, 有安 宏之, 浅原 哲子, 金本 巨哲, 海老原 健, 三浦 晶子, 八十田 明宏, 荒井 宏司, 細田 公則, 中尾 一和
  • Organizer: 第33回日本肥満学会
  • Place of Presentation: 京都市
  • Year and Date: 20121011-12
• [Presentation] 肥満に合併するうつ状態に対するアミリンおよびレプチンの抗うつ作用の検討 (2012)
  • Author(s): 後藤 伸子, 勝浦 五郎, 越智 ゆかり, 山下 唯, 海老原 健, 日下部 徹, 有安 宏之, 金本 巨哲, 三浦 晶子, 八十田 明宏, 荒井 宏司, 細田 公則, 中尾 一和
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 20120419-21
• [Presentation] 急性ストレスによる報酬系に関わる神経核におけるδfosB mRNAの発現変化 (2012)
  • Author(s): 越智 ゆかり, 後藤 伸子, 勝浦 五郎, 山下 唯, 有安宏之, 金本 巨哲, 三浦 晶子, 八十田 明宏, 荒井 宏司, 細田 公則, 中尾 一和
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 20120419-21
• [Book] Mental function and Obesity, Functional Brain Mapping and Endeavor to Understand the Working Brain (2013)
  • Author(s): Yamada-Goto N, Katsuura G, Nakao K
  • Publisher: InTech, Europe