2013 Fiscal Year Final Research Report
Correction model of hemophilia A mice with multicopy of reprogramming factors and factor VIII gene using HAC
Project/Area Number |
24790974
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Hematology
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Research Institution | Tottori University |
Principal Investigator |
KUROSAKI Hajime 鳥取大学, 医学(系)研究科(研究院), 助教 (70464295)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Keywords | 血友病 / 幹細胞 / 再生医療 |
Research Abstract |
Human artificial chromosome (HAC) vectors show considerable promise for gene therapy applications as they have the capacity to deliver an extremely large genetic region and are stably maintained independent of the host chromosome, thus diminishing risks of insertional mutagenesis. In this study, we have developed HAC vectors for gene therapy of hemophilia.
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[Presentation] Toward safe and effective gene- and cell-therapies using human artificial chromosomes and stem cells2013
Author(s)
Narumi Uno, Kana Ueda, Yuichi Iida, Yuna Yakura, Hajime Kurosaki, Katsuhiro Uno, Mitsuhiko Osaki, Tetsuya Ohbayashi, Yasuhiro Kazuki, Masaharu Hiratuka and Mitsuo Oshimura
Organizer
International Conference on Genetic Engineering & Genetically Modified Organisms
Place of Presentation
DoubleTree by Hilton, Raleigh, NC, USA
Year and Date
2013-08-13
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[Presentation] Human artificial chromosomes for gene delivery2012
Author(s)
Oshimura M , Kazuki Y , Hiratsuka M , Ohbayashi T, Iida Y, Uno N, Ueno E, Ueda K, Ohira T, Kurosaki H, Abe S, Kugoh H
Organizer
Pep Talk
Place of Presentation
USA
Year and Date
2012-01-09
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