The role of Aiolos in allergic airway inflammation

2013 Fiscal Year Final Research Report

• Project/Area Number: 24790989
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Chiba University
• Principal Investigator: TAKATORI Hiroaki 千葉大学, 医学部附属病院, 助教 (30568225)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: アレルギー性気道炎症 / ヘルパーT細胞分化

Research Abstract

It has been shown that Aiolos is a transcription factor whose expression is restricted to hemopoietic cells. However, the regulatory mechanisms of Aiolos expression in CD4+ T cells and its roles in allergic inflammation remain largely unknown. In this study, we found that IL-4 induced Aiolos expression in murine CD4+ T cells through a Stat6-dependent manner, whereas Aiolos expression did not affect Th2 cytokine production in CD4+ T cells. We also found that the expression of Aiolos in the lung was up-regulated in OVA-induced allergic airway inflammation but not in papain-induced airway inflammation in mice. In addition, we found that gene expression of Aiolos strongly correlated with those of TNFRSF4 (OX40) and TNFRSF18 (GITR) in human CD4+ T cells. These results suggest that Aiolos may control the function of CD4+ T cells by regulating the expression of OX40 or GITR in CD4+ T cells.

Research Products

• [Journal Article] Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells (2013)
  • Author(s): Takatori H, Kawashima H, Suzuki K, Iwata A, Yokota M, Suto A, Minamino T, Hirose K, Nakajima H
  • Journal Title: J Immunol Volume: 191(7) Pages: 3614-23
  • Peer Reviewed
• [Journal Article] Role of calcium ionophore A23187-induced activation of IkappaB kinase 2 in mast cells (2013)
  • Author(s): Hosokawa J, Suzuki K, Nakagomi D, Tamachi T, Takatori H, Suto A, Nakajima H
  • Journal Title: Int Arch Allergy Immunol Volume: 161 Suppl 2 Pages: 37-43
  • Peer Reviewed
• [Journal Article] Overexpression of CDCA2 in human squamous cell carcinoma : correlation with prevention of G1 phase arrest and apoptosis (2013)
  • Author(s): Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Tanzawa H
  • Journal Title: PLoS One Volume: 8(2) Pages: e56381
  • Peer Reviewed
• [Journal Article] Ultrasound can improve the accuracy of the 2010 American College of Rheumatology/European League against rheumatism classification criteria for rheumatoid arthritis to predict the requirement for methotrexate treatment (2013)
  • Author(s): Nakagomi D, Ikeda K, Okubo A, Iwamoto T, Sanayama Y, Takahashi K, Yamagata M, Takatori H, Suzuki K, Takabayashi K, Nakajima H
  • Journal Title: Arthritis Rheum Volume: 65(4) Pages: 890-8
  • Peer Reviewed
• [Journal Article] Therapeutic potential of B and T lymphocyte attenuator expressed on CD8+ T cells for contact hypersensitivity (2013)
  • Author(s): Nakagomi D, Suzuki K, Hosokawa J, Kobayashi Y, Suto A, Takatori H, Watanabe N, Matsue H, Murphy TL, Murphy KM, Shimada S, Nakajima H
  • Journal Title: J Invest Dermatol Volume: 133(3) Pages: 702-11
  • Peer Reviewed
• [Journal Article] Pre-dinner administration increases the efficacy of proton pump inhibitors on refractory GERD symptoms in connective tissue disease patients (2013)
  • Author(s): Iwata A, Ikeda K, Hirose K, Takatori H, Takahashi K, Sanayama Y, Tanaka S, Suto A, Nakajima H
  • Journal Title: Mod Rheumatol Volume: 23(2) Pages: 357-64
  • Peer Reviewed
• [Journal Article] Overexpression of cell cycle regulator CDCA3 promotes oral cancer progression by enhancing cell proliferation with prevention of G1 phase arrest (2012)
  • Author(s): Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Bukawa H
  • Journal Title: BMC Cancer Volume: 12 Pages: 321
  • Peer Reviewed
• [Journal Article] Annexin A10 in human oral cancer : biomarker for tumoral growth via G1/S transition by targeting MAPK signaling pathways (2012)
  • Author(s): Shimizu T, Kasamatsu A, Yamamoto A, Koike K, Ishige S, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K
  • Journal Title: PLoS One Volume: 7(9) Pages: e45510.
  • Peer Reviewed
• [Presentation] Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells (2013)
  • Author(s): 川島広稔, 高取宏昌, 鈴木浩太郎, 岩田有史, 横田雅也, 須藤明, 南野徹, 廣瀬晃一, 中島裕史
  • Organizer: 第42回日本免疫学会学術集会
  • Year and Date: 20131211-13
• [Presentation] FDG-PET/CT が病勢診断に有用であった炎症性大動脈瘤の1 例 (2013)
  • Author(s): 高取宏昌, 細川淳一, 石坂透, 中島裕史
  • Organizer: 第25回アレルギー学会春期臨床大会
  • Year and Date: 20130511-12
• [Remarks]
  • URL: http://www.m.chiba-u.jp/class/allergy/