2013 Fiscal Year Final Research Report
Measurement of mRNA pattern of inflammatory functional molecules in urinary sediment
| Project/Area Number |
24791038
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Hirosaki University |
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Principal Investigator |
TSURUGA KAZUSHI 弘前大学, 医学(系)研究科(研究院), 助手 (80587014)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 小児腎・泌尿器科学 / 尿沈渣細胞 |
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| Research Abstract |
Viral infections may trigger the onset and worsening of inflammatory conditions of some glomerulonephritis (GN). We examined mRNA expressions of proinflammatory chemokines in urinary sediment from patients with IgAN and PN. Expression retinoic acid inducible-gene I (RIG-I), cc chemokine ligand 5 (CCL5), fractalkine (FKN), monocyte chemoattactant protein 1 (MCP-1) were higher IgAN compared to non-inflammatory renal disease. Moreover, we observed a significant correlation between the expression of FKN and histologically grades of acute and chronic scores. Intense glomerular FKN expression was observed in biopsy specimens from patients with high activity scores. Although further studies are needed, these preliminary observations suggested that measurement of mRNA expressions of proinflammatory chemokines, such as FKN, in urinary sediment could be used as a non-invasive method for predicting the disease activity of GN.
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Author(s)
Imaizumi T, Aizawa T, Hayakari R, Xing F, Meng P, Tsuruga K, Matsumiya T, Yoshida H, Wang L, Tatsuta T, Tanaka H
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Journal Title
Clin Exp Nephrol
Volume: (online ahead of print)
DOI
Peer Reviewed
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[Journal Article] TLR4 signaling induces retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 in mesangial cells2013
Author(s)
Imaizumi T, Aizawa-Yashiro T, Watanabe S, Matsumiya T, Yoshida H, Tatsuta T, Xing F, Meng P, Hayakari R, Tsuruga K, Tanaka H
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Journal Title
J Nephrol
Volume: 26
Pages: 886-893
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Author(s)
Imaizumi T, Aizawa-Yashiro T, Matsumiya T, Yoshida H, Watanabe S, Tsuruga K, Tatsuta T, Xing F, Hayakari R, Meng P, Tanaka H.
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Journal Title
Am J Nephrol
Volume: 37
Pages: 118-125
Peer Reviewed
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