2014 Fiscal Year Final Research Report
The therapeutic research using Autophagy in Tuberous sclerosis complex
| Project/Area Number |
24791074
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
|
|---|
| Research Institution | Oita University |
|---|
Principal Investigator |
|
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 結節性硬化症 / オートファジー |
|---|
| Outline of Final Research Achievements |
In this research, I have tried to elucidate the relationship between mTOR signaling pathway and autophagy in Tuberous sclerosis complex (TSC) and establish new therapeutic strategy using induction of autophagy. In western blotting, control fubroblast induced autophagy with starvation, but TSC fbroblast did not at all. p62, which is decrease with induction of autophagy, showed reduction tendency in both fibroblasts.
|
| Free Research Field |
小児神経病理学
|
