Elucidation of mechanism of pathogenesis of IgA nephropathy forcusing on the mesangial IgA receptors

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791082
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Wakayama Medical University
• Principal Investigator: SHIMA Yuko 和歌山県立医科大学, 医学部, 助教 (60433364)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 小児IgA腎症 / IgA受容体 / FcαR / メサンギウムＩｇＡ沈着

Outline of Final Research Achievements

IgA nephropathy (IgAN) is most common primary chronic glomerulonephritis in the world. Although the pathogenesis of IgAN remains uncertain, immunological abnormalities that leads to the formation of IgA immune complex and mesangial deposition of IgA may play a crucial role of the pathogenesis of IgAN. We reported that some of the patients with IgAN show the disappearance of glomerular IgA deposits after treatments and that the IgAN patients with IgA disappearance showed better renal survival than the IgAN patients without IgA disappearance. So the relationship between the factors of mesangial IgA deposition and the progression of inflammation is important.
And we analyzed the relationship between the degree of expression of IgA receptors and mesangial proliferation. In the study of mesangial IgA receptors expression in renal biopsy specimens of the patients with IgAN, the expression of FcαR showed significant correlation with the degree of mesangial proliferation.

Free Research Field

小児腎臓病学