2014 Fiscal Year Final Research Report
Therapeutic strategy of phenylketonuria fetal model mouse using self-complementary adeno-associated virus vector
| Project/Area Number |
24791106
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
YAGI HIROYA 筑波大学, 医学医療系, 講師 (70625623)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | AAVベクター / 胎児遺伝子治療 |
|---|
| Outline of Final Research Achievements |
It was intended to be introduced and expressed gene long-term immune tolerance a small amount vector by infecting an AAV vector treating Phenylketoruria into fetuses in utero. To examine the most susceptible serotype of the AAV vector, 2, 5, 6 type AAV were made and examined the infectivity of the placental epithelium. Although HPIEpC cells were used and infected with various AAV vectors per cell 10∧6vector particle, expression was not observed any serotype.
|
| Free Research Field |
産科学
|
