2013 Fiscal Year Final Research Report
Neural circuite formation through nuclear receptor ERRgamma and its disturbing mechanism by endocrine disruptor
| Project/Area Number |
24791116
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TANIDA Takashi 京都府立医科大学, 医学(系)研究科(研究院), 助教 (30589453)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | エストロゲン関連受容体（ERR） / エストロゲン受容体（ERα） / 内分泌攪乱物質 / 微量化学物質 / 神経発達 |
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| Research Abstract |
Recent epidemiological studies suggest that the environmental concomitants such as phenols, dioxins, or organochloride pesticides are associated with neurodevelopmental disability including LD, ADHD and autism. The present study tried to elucidate the neurological and endocrinological function of ERR (alpha, beta, gamma) that is one of target molecules for those compounds. It was revealed that all the subtypes of ERRs were expressed in several hypothalamic areas (AVPV, MPOA, VMH) which are crucial for reproductive endocrine function under the control of estrogen receptor (ER) alpha. Molecular studies indicated that ERRbeta reduces the subnuclear mobility of ERalpha and represses its transactivity on the estrogen-response element. ERRgamma was strongly expressed in reticular thalamic nucleus and substantia nigra reticular part of neonatal rat. These results suggest that ERRs contribute to the regulation of neuroendocrine function and the development of sensorimotor control in the brain.
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Research Products
(16 results)
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[Journal Article] Fetal exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin transactivates aryl hydrocarbon receptor-responsive element III in the tyrosine hydroxylase immunoreactive neurons of the mouse midbrain2014
Author(s)
Tanida T, Tasaka K, Akahoshi E, Ishihara-Sugano M, Saito M, Kawata S, Danjo M, Tokumoto J, Mantani Y, Nagahara D, Tabuchi Y, Yokoyama T, Kitagawa H, Kawata M, Hoshi N
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Journal Title
Journal of Applied Toxicology
Volume: 34
Pages: 117-126
DOI
Peer Reviewed
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[Presentation] The molecular basis of neurodevelopmental disability by the fetal and lactational exposure to 2, 3, 7, 8- tetrachlorodibenzo-p-dioxin (TCDD) during the developmental period2012
Author(s)
段上めぐみ, 田阪 健, 須谷 真巳, 木下今日子, 徳本順子, 表原拓也, 小林泰丈, 辰巳敬哉, 谷田任司, 菅野美津子, 赤星英一, 横山俊史, 北川 浩, 星 信彦
Organizer
環境ホルモン学会第15回研究発表会
Place of Presentation
東京大学
Year and Date
20121218-19
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[Presentation] 生後発達期におけるTCDD による神経発達障害の分子基盤2012
Author(s)
段上めぐみ, 田阪健, 木下今日子, 徳本順子, 表原拓也, 小林秦丈, 辰巳敬哉, 谷田任司, 横山俊史, 菅野美津子, 赤星英一, 北川浩, 星信彦
Organizer
第88回日本解剖学会近畿支部学術集会
Place of Presentation
神戸大学
Year and Date
2012-12-01
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