Association study of schizophrenia by focusing on non-coding RNAs and their target genes responding to psychotomimetic drugs.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791202
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: JITOKU Daisuke 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (10613854)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 遺伝子研究 / 統合失調症 / ヒストン / マイクロRNA

Outline of Final Research Achievements

We focused on microRNAs responding to schizophrenomimetic glutamate receptor antagonist and examined their target genes. The subjects were a Japanese cohort (2,000 patients with schizophrenia and 2,000 control subjects). As the result, we detected a significant association between H-Z gene (histone-associatied gene) and the male patients with schizophrenia. The present findings suggest that modification of the H-Z gene signaling pathway warrants further study in terms of the pathophysiology of schizophrenia.

Free Research Field

精神医学