2014 Fiscal Year Final Research Report
Association study of schizophrenia by focusing on non-coding RNAs and their target genes responding to psychotomimetic drugs.
Project/Area Number |
24791202
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
JITOKU Daisuke 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (10613854)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 遺伝子研究 / 統合失調症 / ヒストン / マイクロRNA |
Outline of Final Research Achievements |
We focused on microRNAs responding to schizophrenomimetic glutamate receptor antagonist and examined their target genes. The subjects were a Japanese cohort (2,000 patients with schizophrenia and 2,000 control subjects). As the result, we detected a significant association between H-Z gene (histone-associatied gene) and the male patients with schizophrenia. The present findings suggest that modification of the H-Z gene signaling pathway warrants further study in terms of the pathophysiology of schizophrenia.
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Free Research Field |
精神医学
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