2013 Fiscal Year Final Research Report
The role of Noxa in depression-like behavior
| Project/Area Number |
24791215
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
YAMAGATA Hirotaka 山口大学, 医学(系)研究科(研究院), 助教 (10549934)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | うつ様行動 / 神経可塑性 |
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| Research Abstract |
The Bcl-2 family members have essential roles in apoptosis. It is reported that Bcl-2 family contribute to stress-induced depression-like behavior. In this study, we investigated the expression of BH3-only protein mRNA in the brain of the animal model for depression. The expression of Noxa in the hippocampus was significantly increased. In non-stressed condition, Noxa KO mice showed longer time of social interaction compared to wild-type mice. With social defeat stress, wild-type mice showed a reduced social interaction time, whereas Noxa KO mice did not show such reduction of social interaction time. These results suggested that Noxa might relate to the stress vulnerability.
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[Presentation] The role of noxa in depression-like behavior2013
Author(s)
Hirotaka Yamagata, Tomohiko Shibata, Shusaku Uchida, Koji Otsuki, Teruyuki Hobara, Fumihiro Higuchi, Naoko Abe, Yoshifumi Watanabe
Organizer
11th World Congress of Biological Psychiatry
Place of Presentation
Kyoto International Conference Center, Kyoto, Japan
Year and Date
2013-06-26
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