2013 Fiscal Year Final Research Report
DNA methylation signatures of peripheral leukocytes in schizophrenia
| Project/Area Number |
24791216
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | schizophrenia, / DNA methylation / epigenetic / microarray / monozygotic twins |
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| Research Abstract |
Genome-wide DNA methylation profiling (485,764 CpG sites) of peripheral leukocytes was conducted in the first set of samples (24 medication-free patients with SCZ and 23 non-psychiatric controls) using Infinium HumanMethylation450 Beadchips. Second, a monozygotic twin study was performed using three pairs of monozygotic twins that were discordant for SCZ. Finally, the data from these two independent cohorts were compared.A total of 234 differentially methylated CpG sites that were common between these two cohorts were identified. Of the 234 CpG sites, 153 sites (65.4%) were located in the CGIs and in the regions flanking CGIs (CGI: 40.6%; CGI shore: 13.2%; CGI shelf: 11.5%). Of the 95 differently methylated CpG sites in CGIs, most of them were located in the promoter regions (promoter: 75.8%; gene body: 14 .7%; 3'UTR: 2.1%). Aberrant DNA methylation in SCZ was identified at numerous loci across the whole genome in peripheral leukocytes.
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Research Products
(29 results)
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[Journal Article] An evaluation of association between a novel hippocampal biology related SNP (rs7294919) and schizophrenia2013
Author(s)
Liu J, Numata S, Ikeda M, Watanabe Y, Zheng XB, Luo X, Kinoshita M, Nunokawa A, Someya T, Ohmori T, Bei JX, Chong SA, Lee J, Li Z, Liu J, Iwata N, Shi Y, Li M, Su B
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Journal Title
PLoS One
Volume: 8(11)
Pages: e80696
DOI
Peer Reviewed
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[Journal Article] DNA methylation signatures of peripheral leukocytes in schizophrenia2013
Author(s)
Kinoshita M, Numata S, Tajima A, Shimodera S, Ono S, Imamura A, Iga J, Watanabe S, Kikuchi K, Kubo H, Nakataki M, Sumitani S, Imoto I, Okazaki Y, Ohmori T
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Journal Title
Neuromolecular Med
Volume: 15(1)
Pages: 95-101
DOI
Peer Reviewed
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[Journal Article] Genetic evidence for association between NOTCH4 and schizophrenia supported by a GWAS follow-up study in a Japanese population2013
Author(s)
Ikeda M, Aleksic B, Yamada K, Iwayama-Shigeno Y, Matsuo K, Numata S, Watanabe Y, Ohnuma T, Kaneko T, Fukuo Y, Okochi T, Toyota T, Hattori E, Shimodera S, Itakura M, Nunokawa A, Shibata N, Tanaka H, Yoneda H, Arai H, Someya T, Ohmori T, Yoshikawa T, Ozaki N, Iwata N
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Journal Title
Mol Psychiatry
Volume: 18(6)
Pages: 636-638
DOI
Peer Reviewed
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[Journal Article] Clinical correlates associated with cognitive dysfunction in people with schizophrenia2012
Author(s)
Tanaka T, Tomotake M, Ueoka Y, Kaneda Y, Taniguchi K, Nakataki M, Numata S, Tayoshi S, Yamauchi K, Sumitani S, Ohmori T, Ueno S, Ohmori T
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Journal Title
Psychiatry Clin Neurosci
Volume: 66(6)
Pages: 491-8
DOI
Peer Reviewed
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[Journal Article] Functional genetic variation at the NRGN gene and schizophrenia : evidence from a gene-based case-control study and gene expression analysis2012
Author(s)
Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohnuma T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M
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Journal Title
Am J Med Genet B Neuropsychiatr Genet
Volume: 159B(4)
Pages: 405-13
DOI
Peer Reviewed
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[Presentation] A gender-specific meta-analysis2013
Author(s)
Shu-Suke Numata, Kumiko Kikuchi, Atsushi Tajima, Makoto Kinoshita, Shinji Shimodera, Masahito Tomotake, Issei Imoto, Tetsuro Ohmori. Plasma homocysteine and schizophrenia
Organizer
11th world congress of biological psychiatry
Place of Presentation
Kyoto International Conference Center, 京都府
Year and Date
2013-06-23
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