Biomarker research about PTSD featuring for inflamation.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791225
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: YOSHII Takanobu 京都府立医科大学, 医学(系)研究科(研究院), 講師 (50468261)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: PTSD / ストレス / 小動物MRI

Outline of Final Research Achievements

We seeked bio-marker in PTSD via small animal brain MRI. Single-prolonged stress (SPS: 2hour-restraint, 20min-forced swimming, and ether anesthesia) was applied for PTSD model stress and ex-vivo brain MRI aquisition was conducted. Using voxel-based morphometry, significant 3 atrophic clusters were detected in the sensory area, and thalamus (SPS: n=18, Sham: n=17, cluster-FWE corrected P≦0.). We also conducted immunohistochemistry for IBa-1 as a marker of activated microglia in these areas, and significant increase in IBa-1 immunoreactivity was confirmed. These results suggests that microglial activation may lead to brain atrophy via neuroinnfllamation mechanisms in the paradigm of PTSD model stress.

Free Research Field

精神医学