2013 Fiscal Year Final Research Report
Role of PDEs in antidepressant effects in the hippocampal dentate gyrus.
| Project/Area Number |
24791244
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 抗うつ薬 / 海馬歯状回 / ホスホジエステラーゼ / ドーパミン |
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| Research Abstract |
Recent studies show that chronic SSRI treatment induces novel effects such as increase of the exitability of mature granule cells and expression of dopamine D1 receptors in the dentate gyrus (DG), called dematuration. Here, we investigated the role of PDEs in antidepressant effects, because inhibition of PDE results in increase of D1 receptor signaling. In this study, we revealed that PDE2 and PDE4 modulate the level of D1 receptor signaling in the DG. Combined treatment with fluoxetine and PDE2 and/or PDE4 inhibitors significantly enhanced D1 signaling induced by fluoxetine. These biochemical actions of PDE2 and PDE4 inhibitors may contribute to the development of new antidepressants.
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Research Products
(7 results)
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[Journal Article] Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia2013
Author(s)
Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T
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Journal Title
Neuropsychopharmacology
Volume: 38(8)
Pages: 1409-1425
DOI
Peer Reviewed
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