Protective value of continuous intravenous infusion for radiation-induced myocardial damage

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791269
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: JINGU Keiichi 東北大学, 医学(系)研究科(研究院), 教授 (00451592)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 放射線心筋障害 / ナトリウム利尿ペプチド

Outline of Final Research Achievements

We irradiated to mice's mediastinum with 8 Gy, and then hANP was administrated by continuous intravenous infusion 14 days after irradiation. As control group, we put mice which were not administrated hANP. Six months after irradiation, survived mice were performed MRI and dissected. The group with irradiation showed epicardial thickness and myocardial fibrosis; however, there was no significant differece between the group with irradiation and the group without irradiation. Therefore, hANP was considered to have no protective value for radiation-induced myocardial damage.

Free Research Field

放射線腫瘍学