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2015 Fiscal Year Final Research Report

Breakthrough of normal pharmacokinetics of human inner ear using magnetic resonance imaging after intravenous gadolinium injection

Research Project

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Project/Area Number 24791288
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionNagoya University

Principal Investigator

YAMAZAKI Masahiro  名古屋大学, 医学部附属病院, 病院助教 (40595526)

Project Period (FY) 2012-04-01 – 2016-03-31
Keywords磁気共鳴画像法 / 内耳の生理的薬物動態 / Heavily T2強調3D-FLAIR / ガドリニウム造影剤 / 放射線医学
Outline of Final Research Achievements

Magnetic resonance imaging after intravenous gadolinium injection enable visualization of endolymphatic hydrops of inner ear. However, normal pharmacokinetics of gadolinium injected intravenously in the inner ear is still unclear. The purpose of this study is to make it clear.
In the present study, heavily T2-weighted 3D-FLAIR images of healthy volunteers were obtained on pre- and post-contrast several time points. Based on these imaging data, we revealed the pharmacokinetics of gadolinium injected intravenously in the inner ear perilymph.

Free Research Field

放射線医学

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Published: 2017-05-10  

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