Breakthrough of normal pharmacokinetics of human inner ear using magnetic resonance imaging after intravenous gadolinium injection

2015 Fiscal Year Final Research Report

• Project/Area Number: 24791288
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Nagoya University
• Principal Investigator: YAMAZAKI Masahiro 名古屋大学, 医学部附属病院, 病院助教 (40595526)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 磁気共鳴画像法 / 内耳の生理的薬物動態 / Heavily T2強調3D-FLAIR / ガドリニウム造影剤 / 放射線医学

Outline of Final Research Achievements

Magnetic resonance imaging after intravenous gadolinium injection enable visualization of endolymphatic hydrops of inner ear. However, normal pharmacokinetics of gadolinium injected intravenously in the inner ear is still unclear. The purpose of this study is to make it clear.
In the present study, heavily T2-weighted 3D-FLAIR images of healthy volunteers were obtained on pre- and post-contrast several time points. Based on these imaging data, we revealed the pharmacokinetics of gadolinium injected intravenously in the inner ear perilymph.

Free Research Field

放射線医学