2013 Fiscal Year Final Research Report
Non-invasive assessment of mouse brain tumor by EPR imaging
| Project/Area Number |
24791318
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
EMOTO Miho 札幌医科大学, 医療人育成センター, 研究員 (10578735)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | EPRイメージング / MRI / 酸化還元 / 酸化ストレス / 分子イメージング |
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| Research Abstract |
Electron paramagnetic resonance (EPR) imaging is a noninvasive imaging method for visualizing redox status using nitroxide as an imaging probe.In this project, using an improved EPR imaging system, I showed the distribution and redox status in mouse brain by using some nitroxides, which have five-membered ring or six-membered ring. Three-dimensional EPR image was obtained in about 15 sec from 181 projection data. This data acquisition time was fast enough to visualize and evaluate pharmacokinetics of some nitroxides used in this project. Further, we obtained anatomical information of mouse brain with MRI. By superimposed EPR image on MRI, i clarified behavior of some nitroxides in mouse brain.
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