PET imaging for blood-brain barrier

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791356
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: OKADA Maki 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (00415407)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: PET / 血液脳関門 / アミノイソ酪酸

Outline of Final Research Achievements

We visualized the blood-brain barrier (BBB) opening by 11C-2-aminoisobutyric acid (P11PC-AIB) PET. 11C-AIB significantly and gradually accumulated the BBB-opening side compared with contralateral side. Moreover, the 11C-AIB accumulated area was co-localized with the area stained by Evans blue, the marker of BBB breakdown. The kinetic of 11C-AIB in brain was different from that of Gd-DTPA-enhanced MRI. These results suggest that 11C-AIB PET is a useful method for visualizing BBB opening. However, the accumulating mechanism of 11C-AIB PET is different from that of Gd-DTPA-enhanced MRI.

Free Research Field

核医学