2014 Fiscal Year Final Research Report
The effect of sodium zinc dihydrolipoylhistidinate to treat chemotherapy induced alopecia
| Project/Area Number |
24791385
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Oita University |
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Principal Investigator |
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| Research Collaborator |
INOMATA Masafumi 大分大学, 医学部, 教授 (60315330)
KONO Yohei 豊後大野市民病院, 外科 (90572008)
HIRATSUKA Takahiro 大分大学, 医学部, 病院特任助教 (20600886)
SUGITA Satoshi 大分医療センター, 外科 (20625470)
ASO Yuiko 大分大学, 医学部, 研究員 (60635358)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 乳がん / 脱毛 / 腫瘍学 |
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| Outline of Final Research Achievements |
Hair loss in the anticancer drug treatment period affects the treatment compliance by lowering the QOL of patients. This is a strategic project which focuses not only basic but also places a view to clinical application. We have showed that novel α-lipoic acid derivatives, DHL-HisZnNa, vitamin E derivative ESeroS-GS, and the ETS-GS inhibited the anti-cancer agents induced alopecia. We revealed these novel antioxidants has anti-tumor effect rather, without attenuating the anti-cancer effect with the anti-cancer agent.
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| Free Research Field |
医歯薬学
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