New development of pancreatic cancer stromal control based on the molecular analysis

2013 Fiscal Year Final Research Report

• Project/Area Number: 24791430
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: FUJITA Hayato 九州大学, 医学(系)研究科(研究院), 共同研究員 (40611281)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 膵癌 / 間葉系幹細胞 / 線維増生

Research Abstract

CD90-positive fibroblasts were observed in 93% or more in the analysis of pancreatic stellate cells and this CD90 could be the key surface marker to regulate desmoplasia. In the analysis of pancreatic cancer cells, CD105-positive pancreatic cancer cells showed the specific gene expression of epithelial-mesenchymal transition and these mobility were enhanced by pancreatic stellate cells. In the case of CD166, CD166-negative pancreatic cancer cells showed strong mobility and invasiveness compared with CD166-positive cells. Furthermore, the anti-fibrotic drug "Pirfenidone" inhibited pancreatic cancer desmoplasia mainly contributed by pancreatic stellate cells and it had been suggested that regulation of stroma could suppress progression for pancreatic cancer.

Research Products

• [Journal Article] Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells (2013)
  • Author(s): Kozono S, Ohuchida K, Eguchi D, Ikenaga N, Fujiwara K, Cui L, Mizumoto K, Tanaka M
  • Journal Title: Cancer Research Volume: 73(7) Pages: 2345-56
  • DOI: 10.1158/0008-5472.CAN-12-3180
• [Journal Article] Migrato ry Activity of CD105+ Pancreatic Cancer (2013)
  • Author(s): Fujiwara K, Ohuchida K, Ohtsuka T, M izumoto K, Shindo K, Ikenaga N, Cui L, Takahata S, Aishima S, Tanaka M
  • Journal Title: Cells Is Strongly Enhanced by Pancreat ic Stellate Cells Pancreas Volume: 42(8) Pages: 1283-90
• [Journal Article] CD271+ subpopulation of pancreatic stellate cells correlates with prognosis of pancreatic cancer and is regulated by interaction with cancer cells (2012)
  • Author(s): Fujiwara K, Ohuchida K, Mizumoto K, Shindo K, Eguchi D, Kozono S, Ikenaga N, Ohtsuka T, Takahata S, Aishima S, Tanaka M
  • Journal Title: PLos One Volume: 12
  • DOI: 10.1371/journal.pone.0052682
• [Presentation] Clinical Significance of Stromal CD90 and alpha-SMA Expression in Pancreatic Cancer American Pancreatic Association (2013)
  • Author(s): Sada M, et al
  • Organizer: 44th Annual Meeting
  • Place of Presentation: Miami
  • Year and Date: 2013-10-30
• [Presentation] A CD166 negative subpopulation of pancreatic cancer cells has strong invasive and migratory activity (2013)
  • Author(s): Fujiwara K, et al
  • Organizer: DDW2013
  • Place of Presentation: Orlando
  • Year and Date: 2013-05-18
• [Presentation] Migratory activity of CD105+ pancreatic cancer cells is strongly enhanced by pancreatic stellate cells 2012 Joint Meeting of American Pancreatic (2012)
  • Author(s): Fujiwara K, et al
  • Organizer: Association and International Association of Pancreatology
  • Place of Presentation: Miami
  • Year and Date: 2012-11-03