2013 Fiscal Year Final Research Report
Elucidation of the role of HMGB-1 in the pancreatic cancer
| Project/Area Number |
24791444
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | HMGB-1 |
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| Research Abstract |
High Mobility Group Box Protein (HMGB1) is protein in the nuclei, but it is released outside a cell under the presence of severe inflammation, and it is widely known that it play big roles in the onset of the DIC. On the other hand, it is reported that it participate in the progression and metastasis of cancer, but the bioactivity is unknown enough. The principal aim of this study was to elucidate the expression of High-Mobility Group Box1 in the human pancreatic cancer and the influence of local anti-cancer immunity, and to develop therapeutic strategy effective for pancreatic cancer. But the experiment did not advance according to assumption and we can not achieve an original purpose.
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