2015 Fiscal Year Final Research Report
Postoperative Atrial Fibrillation and Insulin Resistance
| Project/Area Number |
24791453
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 術後心房細動 / インスリン抵抗性 |
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| Outline of Final Research Achievements |
Subjects were 38 patients who underwent cardio-thoracic surgery. Twenty-four-hours monitoring by electrocardiogram was conducted for the detection of postoperative atrial fibrillation for 7 days after surgery. Excised right atrial muscle was quickly frozen and stored for the gene expression analysis of glucose and fatty acid metabolism. Eighteen patients (47%) presented with postoperative atrial fibrillation (POAF group). The gene expression of fatty acid binding protein 3 (FABP3: fatty acid transporter in myocytes) was significantly reduced in the POAF group than in the non-POAF group. Moreover, in the analysis of 12 patients with insulin resistance, the gene expression of fatty acid translocase (CD36: fatty acid transporter into myocytes) tended to be higher in the POAF group than in the non-POAF group (P=0.08). We demonstrated that there is a correlation between POAF and abnormal gene expression of fatty acid metabolism in the myocardium.
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| Free Research Field |
心臓血管外科
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