A network alteration analysis in the central nervous system disorders

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791500
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cerebral neurosurgery
• Research Institution: Osaka University
• Principal Investigator: TANI Naoki 大阪大学, 医学(系)研究科(研究院), 特任研究員 (20598370)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: Default mode network / Restina stage network / 機能的結合 / 側頭葉てんかん / 正常圧水頭症 / 後部帯状回 / 言語性記憶障害

Outline of Final Research Achievements

In the normal healthy subject, we found a strong negative functional connectivity between posterior cingulate cortex, which is one of the important hubs of the default mode network, and the inferior frontal gyrus. This negative functional connectivity has attenuated in the temporal lobe epilepsy patient with verbal memory impairment. However, it is unclear whether this attenuation emerges as the result of the verbal memory impairment or plays a role in causing the verbal memory impairment.
Additionally, we found an alteration in the DMN of patients with iNPH. We showed that the DMN connectivity was reduced in patients with iNPH and it correlated with the severity of their clinical symptoms. The reduction may be reflecting an adaptive response of patients against their impairments.

Free Research Field

脳神経外科