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2013 Fiscal Year Final Research Report

Antitumor Effect of Zoledronic Acid-Loaded Phosphorylated Pullulan on Bone Metastasis Model of Mice.

Research Project

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Project/Area Number 24791548
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionOkayama University

Principal Investigator

TAKEDA Ken  岡山大学, 医歯(薬)学総合研究科, 助教 (70614923)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywordsがん骨転移 / ゾレドロン酸 / ビスフォスフォネート
Research Abstract

We analyzed in vitro and in vivo antitumor effect of the mixture of zoledronic acid and phosphorylated pullulan for human breast cancer cell line. The elution of zoledronic acid released from phosphorylated pullulan exhibited antitumor effect. Phosphorylated pullulan exhibited a drug release property for zoledronic acid. The local administration of the mixture of the mixture of zoledronic acid and phosphorylated pullulan into the metastatic bone tumor model of nude mice exhibited antitumor effect. Furthermore, bone formation was observed around the mixture.

  • Research Products

    (1 results)

All 2013

All Presentation (1 results)

  • [Presentation] Surgical treatment of Giant Cell Tumor of Bone in extremity2013

    • Author(s)
      Ken Takeda
    • Organizer
      International Society of Limb salvage 17th General Meeting
    • Place of Presentation
      ボローニャ(イタリア)
    • Year and Date
      20130911-13

URL: 

Published: 2015-06-25   Modified: 2015-08-05  

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