2013 Fiscal Year Final Research Report

Antitumor Effect of Zoledronic Acid-Loaded Phosphorylated Pullulan on Bone Metastasis Model of Mice.

Research Project

Project/Area Number	24791548
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Orthopaedic surgery
Research Institution	Okayama University
Principal Investigator	TAKEDA Ken 岡山大学, 医歯(薬)学総合研究科, 助教 (70614923)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	がん骨転移 / ゾレドロン酸 / ビスフォスフォネート
Research Abstract	We analyzed in vitro and in vivo antitumor effect of the mixture of zoledronic acid and phosphorylated pullulan for human breast cancer cell line. The elution of zoledronic acid released from phosphorylated pullulan exhibited antitumor effect. Phosphorylated pullulan exhibited a drug release property for zoledronic acid. The local administration of the mixture of the mixture of zoledronic acid and phosphorylated pullulan into the metastatic bone tumor model of nude mice exhibited antitumor effect. Furthermore, bone formation was observed around the mixture.

(1 results)