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2013 Fiscal Year Final Research Report

The efficacy of nitrite for cardioprotection

Research Project

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Project/Area Number 24791607
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Anesthesiology/Resuscitation studies
Research InstitutionSapporo Medical University

Principal Investigator

HIRATA Noyuki  札幌医科大学, 医学部, 助教 (00438045)

Co-Investigator(Renkei-kenkyūsha) YOSHIKAWA Yusuke  札幌医科大学, 医学部, 研究員 (40721759)
Research Collaborator MARUYAMA Daisuke  札幌医科大学, 医学部, 研究員 (60609006)
MIYASHITA Ryu  札幌医科大学, 医学部, 研究員 (50560877)
KAWAGUCHI Ryoichi  札幌医科大学, 医学部, 研究員 (30609003)
Project Period (FY) 2012-04-01 – 2014-03-31
Keywords周術期管理学
Research Abstract

Recently, the number of elderly patients with ischemic heart disease, who receive surgical procedure, are increasing. Therefore, anesthesiologists are required for safety and high quality peri-operative management.
Recent studies have shown that nitrite has cardioprotective effects against ischemia-reperfusion injury. We examined the effects of nitrite on ischemic hearts using rat models. Our results demonstrates that 0.15mg/kg nitrite can attenuate ischemia-induced ventricular arrhythmias. Nitric oxide reduced from nitrite may be involved in this anti-arrhythmia effect via preservation of gap junction proteins, connexin 43. Ischemia-induced arrhythmias leads to a lethal condition in acute coronary syndrome. Therefore, our results highlight a potential of nitrite for cardioprotection not only in peri-operative management but also in emergency medicine.

  • Research Products

    (3 results)

All 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Substrate-dependently modulation of oxidative phosphorylation in isolated mitochondria following in vitro hypoxia and deoxygenation injury2013

    • Author(s)
      Maruyama D, Hirata N, Miyashita R, Kawaguchi R, Yoshikawa Y, Yamakage M
    • Journal Title

      Experimental and Clinical Cardiology

      Volume: 18 Pages: 158-160

    • Peer Reviewed
  • [Presentation] Nitrite attenuates ischemia-induced ventricular arrhythmias by reduction to nitric oxide in rats2013

    • Author(s)
      Maruyama D, Hirata N, Miyashita R, Kawaguchi R, Yoshikawa Y, Yamakage M
    • Organizer
      The annual meeting of the American society of Anesthesiologists
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2013-10-13
  • [Presentation] 亜硝酸塩は NOS を介してラット心筋虚血後心室性不整脈を抑制する2013

    • Author(s)
      丸山大介, 平田直之, 山蔭道明
    • Organizer
      第18回日本心臓血管麻酔学会
    • Place of Presentation
      小倉市
    • Year and Date
      2013-09-27

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Published: 2015-06-25  

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