2013 Fiscal Year Final Research Report
Effects of opioid on anticancer agent sensitivity in cancer cells
| Project/Area Number |
24791620
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 癌 / オピオイド / 抗癌剤感受性 |
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| Research Abstract |
According to previous studies, it is likely that opioids directly regulate the growth of cancer cells by modulating cell proliferation and/or apoptosis. We examined the effects of several opioids on proliferative activity in human colon cancer cell lines (HCT116 and HT29). It is demonstrated that exposure of morphine to HCT116 cells for 6 h resulted in enhanced proliferation. To the contrary, morphine exposure to HT29 cells for 24 h inhibited cell proliferation. The mu opioid agonists, fentanyl and remifentanil did not alter the proliferative activity. Therefore, it is suggested that morphine may affect cell proliferation through a certain pathway other than mu opioid receptor.
In addition, we investigated whether morphine and fentanyl alter the sensitivity to 5-fluorouracil. The pretreatment with morphine and fentanyl did not alter sensitivity to 5-fluorouracil in HCT116 cells. This is the first study to investigate the effects of opioids on subsequent chemotherapy.
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