2015 Fiscal Year Final Research Report
Investigation of antimicrobial administration based on PK-PD using in vivo model of urinary tract infection due to drug-resistant Echerichia coli
| Project/Area Number |
24791651
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 尿路感染症 / 大腸菌 / 薬剤耐性 / ESBL産生菌 / 抗菌薬 / 治療法 / 薬物動態／薬力学 / マウス感染モデル |
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| Outline of Final Research Achievements |
In clinical study, characterization of clinical isolates of Escherichia coli (E. coli) isolated from urinary tract infection; development of culture medium in which drug-resistant E. coli isolates could be selectively cultured; investigation of administration duration of antimicrobials against uncomplicated cystitis; evaluation of penetration of various antimicrobials to human epididymis tissue, were completely performed.
In basic research, analysis of bacterial gene related with drug resistance; construction of mice model of urinary tract infection; evaluation of administration manner of antimicrobials using the model, were performed. However, effective dose and duration of antimicrobial treatment against biofilms in urinary tract could not be clarified.
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| Free Research Field |
泌尿器科
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