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2013 Fiscal Year Final Research Report

Establishment of a new therapeutic strategy of uterine sarcoma using a primary culture cell mass

Research Project

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Project/Area Number 24791703
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionOsaka University

Principal Investigator

KIMURA Toshihiro  大阪大学, 医学部附属病院, 助教 (90584524)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords婦人科腫瘍学
Research Abstract

Uterine leiomyosarcoma is a rare disease in gynecology, but it is one of the worst disease prognosis. I considered that the effect of chemotherapy is low is one of the factors. I tried to create a primary culture cell mass of uterine leiomyosarcoma patient specimen using a new culture method that has been reported in other types of cancer recently. I have made a primary culture cell mass from collected samples of uterine smooth muscle tumors from several patients obtained informed consent in writing. It was confirmed that the primary cell masses to form spheroids within 24 hours in all cases, it is possible to create a primary cultured cell mass by reported methods. And succeeded in long-term culture of primary cells mass uterine leiomyosarcoma using the culture medium plus growth factors in serum-free medium and subsequently

  • Research Products

    (2 results)

All 2013 2012

All Presentation (2 results)

  • [Presentation] CTOS 培養法を用いた子宮体癌に対する抗癌剤感受性試験2013

    • Author(s)
      清原裕美子, 木村敏啓 吉野潔 平松宏祐 松崎慎哉 小林栄仁 上田豊 藤田征巳 井上正宏 榎本隆之 木村正
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌
    • Year and Date
      20130510-13
  • [Presentation] Chemo-sensitivity test using cancer-tissue originated spheroids(CTOSs) of endometrial cancer2012

    • Author(s)
      Kiyohara, Y. Kimura, T. Yoshino, K. Morimoto, A. Ueda, Y. Fujita, M. Inoue, M. Enomoto, T. Kimura, T.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      20120919-21

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Published: 2015-06-25  

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