2013 Fiscal Year Final Research Report
Likelihood to the new treatment of ovarian clear cell adenocarcinoma which classified individualization of the treatment
Project/Area Number |
24791724
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
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Research Institution | Tokai University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Keywords | 卵巣明細胞腺癌 / mTOR / HIF-1 / mTOR阻害剤 / everolimus / 治療の個別化 / 婦人科腫瘍学 / 婦人科病理学 |
Research Abstract |
(1) The mTOR inhibitor (Everolimus) of the mTOR - HIF-1 pathway restrained it. evelorimus provided suppression of the cellular proliferative capacity and promotion of degradation pathway (VHL) of HIF-1. As for this drug, the likelihood as a new therapeutic drug through the mTOR - HIF-1 pathway in the ovarian clear cell adenocarcinoma was expected. (2) The effect of treatment in vivo showed antitumor effect more in Everolimus + CDDP group than an Everolimus single group. (3) As a treatment marker of the clear cell adenocarcinoma, expression patterns of HIF-1, a positive rate of p-mTOR may be effective.
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[Journal Article] Defect of tropomyosin-related kinase B isotype expression in ovarian clear cell adenocarcinoma2014
Author(s)
Goto Y, Kametani Y, Kikugawa A, Tsuda B, Miyazawa M, Kajiwara H, Terao Y, Takekoshi S, Nakamura N, Takeda S, Mikami M
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Journal Title
Biosci Trends
Volume: 8(2)
Pages: 93-100
URL
Peer Reviewed
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[Journal Article] Value of metastin receptor immunohistochemistry in predicting metastasis after radical nephrectomy for pT1 clear cell renal cell carcinoma2013
Author(s)
Shoji S, Nakano M, Tomonaga T, Kim H, Hanai K, Usui Y, Nagata Y, Miyazawa M, Sato H, Tang XY, Osamura YR, Uchida T, Terachi T, Takeya K
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Journal Title
Clin Exp Metastasis
Volume: 30(5)
Pages: 607-14
DOI
Peer Reviewed
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[Journal Article] Glycan Profiling of Endometrial Cancers Using Lectin Microarray2012
Author(s)
Nishijima, Y, Toyoda M, Yamazaki-Inoue M, Sugiyama T, Miyazawa M, Muramatsu T, Nakamura K, Narimatsu H, Umezawa A, Mikami M
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Journal Title
Genes Cells
Volume: 17(10)
Pages: 826-36
DOI
Peer Reviewed
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[Journal Article] Enhanced Expression of Sulfatide, a Sulfated Glycolipid, in Well-Differentiated Endometrial Adenocarcinoma2012
Author(s)
Sugiyama T, Miyazawa M, Mikami M, Goto Y, Nishijima Y, Ikeda M, Hirasawa T, Muramatsu T, Takekoshi S, Iwamori M.
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Journal Title
Int J Gynecol Cancer
Volume: 22(7)
Pages: 1192-7
DOI
Peer Reviewed
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[Presentation] Enhanced Expression of Sulfatide, a Sulfated Glycolipid, In Uterine Cervical Adenocarcinomas2013
Author(s)
Miyazawa M, Sugiyama T, Miyazawa M, Fujii S, Ikeda M, Shida M, Hirasawa T, Muramatsu T, Matsui N, Kajiwara H, Iwamori M, Mikami M
Organizer
第72回日本癌学会学術総会
Place of Presentation
横浜/パシフィコ横浜
Year and Date
2013-10-03
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[Presentation] 婦人科腫瘍におけるThymidine phosphorylase の治療マーカーとしての可能性2013
Author(s)
信田政子, 宮澤麻里子, 宮澤昌樹, 矢坂美和, 楢山知明, 楢山知紗, 菅野秀俊, 井浦文香, 田島敏樹, 塚田ひとみ, 池田仁恵, 平澤猛, 梶原博, 村松俊成, 中村直哉, 安田政実, 三上幹男
Organizer
第54回日本婦人科腫瘍学会学術講演会
Place of Presentation
東京/ホテル グランパシフィック LE DAIBA
Year and Date
2013-07-19
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[Presentation] 卵巣漿液性境界悪性腫瘍28 例の臨床病理学的検討2013
Author(s)
加藤智美, 安田政実, 鈴木裕之, 長谷川幸清, 藤原恵一, 宮澤昌樹, 梶原博, 平澤猛, 大金直樹, 亀田陽一, 加藤久盛
Organizer
第54回日本婦人科腫瘍学会学術講演会
Place of Presentation
東京/ホテル グランパシフィック LE DAIBA
Year and Date
2013-07-19
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[Presentation] Type II 子宮体癌の予後不良因子にmTOR-HIF-HDAC7 pathway が関与している2013
Author(s)
平澤猛, 宮澤昌樹, 宮澤麻里子, 楢山知紗, 矢坂美和, 楢山知明, 菅野秀俊, 田島敏樹, 井浦文香, 塚田ひとみ, 池田仁恵, 信田政子, 村松俊成, 安田政実, 三上幹男
Organizer
第54回日本婦人科腫瘍学会学術講演会
Place of Presentation
東京/ホテル グランパシフィック LE DAIBA
Year and Date
2013-07-19
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[Presentation] 卵巣明細胞腺癌の予後改善を目指して上皮性卵巣癌におけるHIF-1 の転写活性とHDAC7 発現の意義2013
Author(s)
宮澤昌樹, 平澤猛, 宮澤麻里子, 安田政実, 加藤智美, 梶原博, 信田政子, 池田仁惠, 松井成明, 村松俊成, 三上幹男
Organizer
第54回日本婦人科腫瘍学会学術講演会(ワークショップ)
Place of Presentation
東京/ホテル グランパシフィック LE DAIBA
Year and Date
2013-07-19
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[Presentation] 卵巣明細胞腺癌の189 例の臨床病理学的検討2013
Author(s)
鈴木裕之, 安田政実, 加藤智美, 清水道生, 吉田正行, 津田均, 宮澤昌樹, 梶原博, 長谷川幸清, 藤原恵一, 岡垣竜吾, 石原理
Organizer
第102回日本病理学会総会
Place of Presentation
札幌/ロイトン札幌
Year and Date
2013-06-06
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[Presentation] An orthotopic uterine cervical cancer model in rats to determine the role of glycolipids for lymph node metastasis2012
Author(s)
Miyazawa M, Sugiyama T, Nishijima Y, HirasawaT, Naito K, Kamijo A, Matsui N, Miyazawa M, Muramatsu T, Iwamori M, Mikami M
Organizer
第71回日本癌学会学術総会
Place of Presentation
札幌/ロイトン札幌
Year and Date
2012-09-21
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[Presentation] Enhanced expression of sulfatide, a sulfated glycolipid, in uterine cervical adenocarcinomas2012
Author(s)
Miyazawa M, Sugiyama T, Nishijima Y, Ikeda M, Shida M, Hirasawa T, Muramatsu T, Matsui N, Miyazawa M, Iwamori M, Mikami M
Organizer
14th International Congress of Histochemistry and Cytochemistry (ICHC 2012)
Place of Presentation
京都/ Kyoto International Conference Center
Year and Date
2012-08-27
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