2013 Fiscal Year Final Research Report
Autophagy regulates galectin-4 expression in the rat trophoblast cell line and affects its differentaiton
| Project/Area Number |
24791726
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | Galectin-４ / Autophagy / MMP / Ｉnvasive trophoblast / Ｐｌａｃｅｎｔａ |
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| Research Abstract |
This study aimed to investigate the expression of Gal4 in placentation. We utilized Rcho-1 cells derived from rat placenta and this cell line has been well established as a model system for trophoblast differentiation. The expression of Gal4 was revealed to be lower in differentiated Rcho-1 cells than that in proliferative cells. Of interest, overexpression of Gal4 during Rcho-1 differentiation resulted in moderate reduction of both cell mobility and cell enlargement. Notably, immunohistochemical analysis showed that Gal4 is preferentially located in the maternal-fetal zone of rat placenta, indicating that Gal4 would negatively regulate differentiation of Rcho-1 cells and/or limit their invasive property.
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Research Products
(13 results)
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[Journal Article] Expression pattern of Galectin 4 in rat placentation2012
Author(s)
Arikawa T, Simamura E, Shimada H, Nishi N, Tatsuno T, Ishigaki Y, Tomosugi naohisa, Yamahiro C, Hata T, Takegami T, Nakamura T, Mogami H, Yamaguchi K, Otani H, Hatta T, and Shoji H
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Journal Title
Placenta (Short Communication)
Volume: 33(10)
Pages: 885-7
Peer Reviewed
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