2014 Fiscal Year Final Research Report
A role of progesterone receptor in uterine smooth muscle as human parturition
| Project/Area Number |
24791728
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | プロゲステロン / オキシトシン / バゾプレッシン / GPR30 / 陣痛発来 |
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| Outline of Final Research Achievements |
Our objective was to determine how expression of Progesterone receptor and GPR30, vasopressin receptor change in human uterine smooth muscle using real time PCR.It was suggested that PR and GPR30,vasopressin V1α receptor play a important role in uterine contraction and human parturition.The expression of the vasopressin V1α receptor in uterine smooth muscle was evaluated by immunohistochemistry. As a result,patients in placenta previa underwent the local injection of a vasopressin solution into the placental implantation site after placental delivery. The mean estimated blood loss was significantly lower in the vasopressin group than in the control group. The local injection of vasopressin into the placental implantation site significantly reduced the blood loss without increasing the morbidity.
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| Free Research Field |
医歯薬学
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