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2015 Fiscal Year Final Research Report

Elucidation of new ca2+-releasing molecule and its mechanism for infertility treatment

Research Project

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Project/Area Number 24791731
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionTokyo Medical University (2013-2015)
National Research Institute for Child Health and Development (2012)

Principal Investigator

Harada Yuichirou  東京医科大学, 医学部, 助手 (80570168)

Project Period (FY) 2012-04-01 – 2016-03-31
Keywords受精 / Ca2+濃度上昇 / Citrate Synthase-like
Outline of Final Research Achievements

Fertilization is essential event for development. However, there is a lot of person who suffer from infertility. And so, I elucidated the factor which concern with fertilization in order to assist for infertility. As a result, citrate synthase-like was found as the new factor in mouse, the mammal model. Citrate synthase-like triggered Ca2+ increase in egg cytoplasm on introducing into the egg, and then was began the development of zygote. Also, enzyme activity in citrate synthase-like or interaction between other molecules and citrate synthase-like seems to be concerned with Ca2+ increase in egg cytoplasm. Furthermore, I am intend to clarify functions and mechanism of citrate synthase-like in fertilization.

Free Research Field

発生生物学

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Published: 2017-05-10  

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