2014 Fiscal Year Final Research Report
Transient hyperpolarization mechanism of the medial vestibular nucleus neurons to ischemia
Project/Area Number |
24791744
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Otorhinolaryngology
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Research Institution | Gunma University |
Principal Investigator |
SHINO Masato 群馬大学, 医学部附属病院, 助教 (20550015)
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Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 内側前庭神経核 / 虚血 / パッチクランプ / 発火特性 |
Outline of Final Research Achievements |
We investigated electrophysiological response of MVN (Medial Vestibular Nucleus) neurons for transient ischemia. Transient ischemia induced transient hyperpolarization and pause of spontaneous firing. Transient hyperpolarization was attributed to intrinsic membrane property of MVN neurons. ATP sensitive potassium channel blocker, glibenclamide inhibited ischemia-induced transient hyperpolarization.
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Free Research Field |
医歯薬学 耳鼻咽喉科
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